Canarypox Virus

An avipoxvirus and etiologic agent of canarypox, a disease of wild and captive birds, which can enter but not survive and multiply in human cells; it was proposed as a live vector for HIV vaccines, as it can carry a large quantity of foreign genes
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However, 4 samples (18%) had antibody to canarypox virus antigen with test sample and negative control ratios (P/N values) ranging from 2.
Live canarypox virus that expresses the rabies virus glycoprotein has been licensed in the USA as a parenteral monovalent vaccine for cats and as a combination rabies vaccines for cats with feline panleukopenia virus, feline parvovirus, feline calicivirus vaccines included in the product (51).
Recombinant canarypox virus vaccine carrying the prM/E genes of West Nile virus protects horses against a West Nile virus-mosquito challenge.
Both strains were found in all 3 passerine taxa, and sequences from both strains were less than 5% different from each other and from canarypox virus.
Two vaccines are available for vaccinating equines: an inactivated WNV vaccine and a recombinant vaccine that uses canarypox virus to express WNV antigens (44,45).
The book finishes with presentations on a novel principle of attenuation for developing new generation live flavivirus vaccines, on tick-borne encephalitis, and on a recombinant vaccine developed from a canarypox virus carrying the prM/E genes of West Nile virus that will protect horses against a West Nile virus--mosquito challenge, and on diagnosis of zoonotic viral encephalitis.
The prime-boost regimen uses Merck's replication-defective adenovirus type 5 vector (Ad5) vaccine candidate first, followed by the canarypox virus vector (ALVAC) vaccine candidate from Aventis Pasteur, the vaccines business of Aventis.
The two companies will combine the ALVAC canarypox virus platform of Aventis Pasteur, the vaccines business of Aventis, and Vivalis' proprietary avian stem cell platform to enable Aventis Pasteur to improve the large-scale production of several ALVAC vaccine candidates.