An endophytic fungus from Camptotheca acuminata
that produces camptothecin and analogues.
nepalensis, Camptotheca acuminata
, and frequently Lindera Thunb.
New camptothecin and ellagic acid analogues from the root bark of Camptotheca acuminata
CZ48 is a derivative of extracts from a Chinese tree, the Camptotheca Acuminata
, which more than 45 years ago showed potent anticancer activity against a type of mouse leukemia.
Recently, researchers at the Stehlin Foundation for Cancer Research in Houston announced impressive results treating pancreatic cancer with 9-Nitro Camptothecin (9NC), made from the Chinese Camptotheca acuminata
Known as the "tree of joy" in China, Camptotheca acuminata
may prove to be a lifesaver for thousands of cancer patients around the world, according to a story in The Forestry Source.
358), a compound from the Chinese Camptotheca acuminata
Camptothecin is an anticancer alkaloid that was originally isolated from the bark and stem wood of Camptotheca acuminata
, a small tree native to China.
The main source of CPT is the Chinese tree Camptotheca acuminata
CPT-11 is a camptothecin analog obtained from the Chinese tree camptotheca acuminata
that kills tumor cells by inhibiting the nuclear enzyme topoisomerase I and interrupting the DNA replication process.
These derivatives are less stable and may not be as effective as neat camptothecin derived from the Chinese tree, Camptotheca acuminata
CPT is produced by several plant species belonging to the Asterid clade (Larsson, 2007); among them, Camptotheca acuminata
Decaisne (Nyssaceae) and Nothapodytes nimmoniana (Graham) Mabb.