CAMK4

(redirected from Camk)
Also found in: Acronyms, Wikipedia.

CAMK4

A gene on chromosome 5q21.3 that encodes a multifunctional serine/threonine protein kinase, which is part of the calcium-triggered CaMKK-CaMK4 signalling cascade and regulates, mainly by phosphorylation, the activity of transcription activators (e.g., CREB1, MEF2D, JUN and RORA). These activators play key roles in immune response, inflammation and memory consodilation. In the thymus, CAMK4 regulates the CD4/CD8 (double positive thymocytes) selection threshold during T-cell ontogeny; it also play a role in transcriptional regulation in lymphocytes, neurons and male germ cells, and is expressed in the brain, thymus, CD4 T-cells and in epithelial ovarian cancers.
Mentioned in ?
References in periodicals archive ?
Previous reports demonstrated that treatment of cultured hippocampal neurons with the CaMK kinase inhibitor STO-609 (2-5 [micro]M) inhibits CaMKI but not CaMKII (Wayman et al.
These observations and the ability of Ang II to cause activation of EGFR led to the hypothesis that CaMK II is involved in Ang II-induced transactivation of EGFR and hypertrophy in VSMC.
This unique collection of 84 structurally diverse and potent inhibitors, which mainly target the CMGC, CaMK, AGC and STE families of kinases, serves as a complement to the InhibitorSelect[TM] 96-well Protein Kinase Library II.