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bicalutamide |
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bicalutamide /bi·ca·lu·ta·mide/ (bi?kah-loo´tah-mid) an antiandrogen used in the treatment of prostatic carcinoma. bicalutamide Warning - Hazardous drug! Casodex Pharmacologic class: Nonsteroidal antiandrogen Therapeutic class: Antineoplastic Pregnancy risk category X ActionAntagonizes effects of androgen at cellular level by binding to androgen receptors on target tissues AvailabilityTablets: 50 mg ⊘Indications and dosages ➣ Metastatic prostate cancer Adults: 50 mg P.O. once daily Contraindications• Hypersensitivity to drug PrecautionsUse cautiously in: Administration• Know that drug is given in combination with luteinizing hormone-releasing hormone (LHRH).
Adverse reactionsCNS: headache, weakness, dizziness, depression, hypertonia, paresthesia, lethargy CV: chest pain, peripheral edema, vasodilation, hypertension, thromboembolic disease EENT: pharyngitis GI: nausea, vomiting, diarrhea, constipation, abdominal pain, anorexia, dry mouth GU: urinary tract infection Musculoskeletal: bone and back pain Respiratory: dyspnea, cough Skin: rash, alopecia Other: food distaste, weight gain, edema, pain, hot flashes, flulike symptoms InteractionsDrug-drug. Warfarin: increased bicalutamide effects Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, cholesterol: increased levels Hemoglobin, white blood cells: decreased values Patient monitoring• Monitor prostate-significant antigen levels, CBC, and liver and kidney function test results. Patient teaching• Instruct patient to take drug at same time each day, along with prescribed LHRH analog. |
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