psammoma body

(redirected from Calcospherites)

psammoma body

a round layered mass of calcareous material occurring in benign and malignant epithelial and connective tissue neoplasms and in some chronically inflamed tissue.
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Psammoma body
A term for a round, laminated, 20–100-µm diameter calcified mass seen by light microscopy, which corresponds to degenerated papillary clusters of cellular debris. It is a very common finding in benign prostate hypertrophy, and may occur in benign and malignant epithelial neoplasms—e.g., papillary carcinomas of the thyroid, ovary, endometrium, pancreas, and kidney—meningiomas, benign ‘sugar tumour’ of lung, mesothelioma, mesothelial cell hyperplasia, bronchioloalveolar carcinoma; ovarian serous cystadenoma, and dystrophic calcification of matrix vesicles and desmoid tumours

psammoma body

A laminated calcified body seen in certain types of tumors and sometimes associated with chronic inflammation.
See also: body
References in periodicals archive ?
Histologically it is characterized by a diffuse infiltration of the colonic mucosa by sheets of large macrophages with eosinophilic granular cytoplasm and characteristic cytoplasmic calcospherites (Michaelis-Gutmann bodies), which are typically positive with Prussian blue and von Kossa stains.
INTRODUCTION: Pulmonary Alveolar Microlithiasis is rare diffuse lung disease of unknown Cause in which diffuse accumulation of numerous calcospherites in the alveolar space with or without thickened interstitium.
10) Confirmatory diagnosis can be established by open lung or transbronchial biopsy, showing intra-alveolar calcospherites, which in turn represent laminated calcium phosphate concretions.
17) Furthermore, biglycan was able to increase the coalescence of calcospherites (21) and apatite formation.
Calcospherites (psammoma or calcific bodies) may be seen.
Many of Wagge's conclusions were formed by Iris earlier experiments (Wagge 1951) that showed migrating epithelial cells were responsible for secretion of both the organic membranes and the crystals of calcium carbonate within the calcospherites (conchiolin compartments).
Calcospherites and occasionally metaplastic bone are described.
1) It is characterized by circumscription or encapsulation, trabecular growth pattern, polygonal and elongated cells, nuclear cytoplasmic inclusions and grooves, hyaline material, dilated sinusoids, laminated calcospherites, and cytoplasmic yellow bodies.
Ganglioglioma often presents radiologically as a mural nodule within a cyst and exhibits several helpful diagnostic features, including higher cellularity, dysmorphic or binucleate neurons unassociated with pink cells, pilocytic morphology of the glial component, calcospherites, desmoplasia, and perivascular lymphocytic infiltrates.
Microscopically, malakoplakia is characterized by aggregates of histiocytes, the Von Hanseman cells, with Michaelis-Gutmann calcospherites.
Previous reports of fine-needle aspiration of dermoid cysts from other sites have demonstrated various cytologic findings, including nucleated and anucleated squamous cells, hair, keratinous debris, cholesterol, calcospherites (calcium deposits), and inflammatory cells.
1,8,9] In tumoral calcinosis, the calcium hydroxyapatite crystals show amorphous basophilic psammoma body-like calcospherites and do not demonstrate any birefringence in the sections stained with H&E or the Shidham method (V.