CACNB4

(redirected from Calcium channel voltage-dependent subunit beta 4)

CACNB4

A gene on chromosome 2q22-q23 that encodes a beta subunit of a voltage-dependent calcium channel, which plays a regulatory role in calcium channel function by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling alpha-1 subunit membrane targeting.

Molecular pathology
CACNB4 mutations have been associated with idiopathic generalised epilepsy and juvenile myoclonic epilepsy.
References in classic literature ?
For as the sea-fight at Salamis and the battle with the Carthaginians in Sicily took place at the same time, but did not tend to any one result, so in the sequence of events, one thing sometimes follows another, and yet no single result is thereby produced.
Being established in that position, and having deliberately resolved to make himself prince and to seize by violence, without obligation to others, that which had been conceded to him by assent, he came to an understanding for this purpose with Amilcar, the Carthaginian, who, with his army, was fighting in Sicily.
The dark and fearful sea of the subtle Ulysses' wanderings, agitated by the wrath of Olympian gods, harbouring on its isles the fury of strange monsters and the wiles of strange women; the highway of heroes and sages, of warriors, pirates, and saints; the workaday sea of Carthaginian merchants and the pleasure lake of the Roman Caesars, claims the veneration of every seaman as the historical home of that spirit of open defiance against the great waters of the earth which is the very soul of his calling.
Now of those principles on which the Carthaginians have established their mixed form of government, composed of an aristocracy and democracy, some incline to produce a democracy, others an oligarchy: for instance, if the kings and the senate are unanimous upon any point in debate, they can choose whether they will bring it before the people or no; but if they disagree, it is to these they must appeal, who are not only to hear what has been approved of by the senate, but are finally to determine upon it; and whosoever chooses it, has a right to speak against any matter whatsoever that may be proposed, which is not permitted in other cases.
Thus, in order to enunciate here only summarily, a law which it would require volumes to develop: in the high Orient, the cradle of primitive times, after Hindoo architecture came Phoenician architecture, that opulent mother of Arabian architecture; in antiquity, after Egyptian architecture, of which Etruscan style and cyclopean monuments are but one variety, came Greek architecture (of which the Roman style is only a continuation), surcharged with the Carthaginian dome; in modern times, after Romanesque architecture came Gothic architecture.
The son Of Macedonian Philip had ere these Won Asia, and the throne of Cyrus held At his dispose; young Scipio had brought down The Carthaginian pride; young Pompey quelled The Pontic king, and in triumph had rode.
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