Calabar bean


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phy·so·stig·ma

(fī'sō-stig'mă),
The dried seed of Physostigma venenosum (family Leguminosae), a vine of western Africa; it contains the alkaloids physostigmine (eserine), eseramine, eseridine (geneserine) and physovenine; at toxic doses, it causes vomiting, colic, salivation, diarrhea, convulsions, sweating, dyspnea, vertigo, slow pulse, and extreme prostration.
[G. physa, bellows, + stigma, a mark, spot; so called because of the shape of the stigma]

Calabar bean

(kăl′ə-bär)
n.
The poisonous seed of a tropical western African woody vine (Physostigma venenosum) in the pea family, the source of physostigmine.

Calabar bean

Herbal medicine
A climbing vine native to Africa that contains physostimine, which causes death by inducing muscle contractions to the point of rigidity.
 
Effects
Pupillary constriction, stimulates smooth muscle of the gastrointestinal tract, causing brachycardia and hypertension; synthetic derivatives (e.g., neostigmine) are used for myasthenia gravis, and in ophthalmology to prevent glaucoma.

Calabar bean

The poisonous seed of the African plant Physostigma venenosum , the source of the drug PHYSOSTIGMINE.