infantile cortical hyperostosis(redirected from Caffey-Silverman syndrome)
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Related to Caffey-Silverman syndrome: Caffey Syndrome
excessive growth of bony tissue. adj., adj hyperostot´ic.
frontal internal hyperostosis (hyperostosis fronta´lis inter´na) a new formation of bone tissue protruding in patches on the internal surface of the cranial bones in the frontal region, most commonly affecting women near menopause.
generalized cortical hyperostosis a hereditary disorder beginning during puberty, marked by osteosclerosis of the skull, mandible, clavicles, ribs, and diaphyses of long bones, associated with elevated blood alkaline phosphatase.
infantile cortical hyperostosis a syndrome seen in infants under six months of age, marked by fever, arthralgias, and swelling and cortical thickening of facial, trunk, and long bones. Called also Caffey's disease.
in·fan·tile cor·ti·cal hy·per·os·to·sis[MIM*114000]
neonatal subperiosteal bone formation over many bones, especially the mandible, clavicles, and the shafts of long bones; it follows fever, usually appearing before 6 months of age and disappearing during childhood; familial cases are inherited as autosomal dominant.
infantile cortical hyperostosis
a familial disorder characterized in an infant by subperiosteal bone formation over many bones, causing swellings and tenderness in the affected areas. The child also tends to be feverish and irritable. The mandible is most commonly involved. Radiographs indicate areas of new bone growth beneath the periosteum. It appears before 6 months of age and disappears during childhood. Also called Caffey's disease.
Caffey diseaseAn autosomal dominant condition MIM 114000 characterised by fever, inflammation, swelling of affected bones (tibia, mandible, ulna and facial bones) and restlessness.
Caffey disease is linked to a mutation of COL1A1.
infantile cortical hyperostosisCaffey disease An AD condition characterized by early onset hyperostosis and neo-osteogenesis, of facial and, less commonly, long bones, soft tissue swelling, hyperirritability, dysphagia, fever, pleuritis Lab ↑ ESR, alk phos
Caffey,John Patrick, U.S. physician, radiologist, and pediatrician, the father of pediatric radiology, 1895-1978.
Caffey-Silverman syndrome - Synonym(s): Caffey syndrome
Caffey disease - Synonym(s): Caffey syndrome