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amlodipine besylate and atorvastatin calcium |
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amlodipine besylate and atorvastatin calcium
Caduet Pharmacologic class: Calcium channel blocker, HMG-CoA reductase inhibitor Therapeutic class: Antihypertensive, antianginal, lipid-lowering agent Pregnancy risk category X ActionAmlodipine inhibits influx of extracellular calcium ions, thereby decreasing myocardial contractility, relaxing coronary and vascular muscles, and reducing peripheral resistance. Atorvastatin inhibits HMG-CoA reductase, which catalyzes first step in cholesterol synthesis; this action reduces serum cholesterol and low-density lipoprotein (LDL) levels; atorvastatin also moderately increases concentration of high-density lipoproteins (HDLs). AvailabilityTablets: (amlodipine besylate/atorvastatin calcium) 2.5/10 mg, 2.5/20 mg, 2.5/40 mg, 5/10 mg, 5/20 mg, 5/40 mg, 5/80 mg, 10/10 mg, 10/20 mg, 10/40 mg, 10/80 mg ⊘Indications and dosages ➣ Patients for whom treatment with both amlodipine and atorvastatin is appropriate, such as those with hypertension (used alone or combined with other antihypertensives), coronary artery disease, cardiovascular disease prevention, heterozygous familial or nonfamilial hypercholesterolemia, homozygous familial hypercholesterolemia, elevated serum triglycerides, or dysbetalipoproteinemia Adults: Dosage individualized based on efficacy of and tolerance for each component. Maximum amlodipine dosage: 10 mg P.O. daily; maximum atorvastatin dosage: 80 mg P.O. daily. Dosage adjustment• Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) more than three times upper limit of normal Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: Administration• Before starting therapy, patient should attempt to control hypercholesterolemia with appropriate diet, exercise, and weight reduction (if obese) and should receive treatment for other underlying medical problems.
Adverse reactionsAmlodipine component CNS: dizziness, headache, fatigue, somnolence CV: palpitations, chest pain, arrhythmias EENT: abnormal vision, conjunctivitis, diplopia, eye pain, tinnitus GI: nausea, abdominal pain, dry mouth GU: frequent urination, urination disorder, nocturia Hematologic: purpura, leukopenia, thrombocytopenia Metabolic: hyperglycemia Skin: flushing, erythema multiforme Other: edema, increased sweating, thirst Atorvastatin component CNS: headache, migraine, asthenia, insomnia, dizziness, malaise, depression, peripheral neuropathy, somnolence, amnesia, abnormal dreams, emotional lability, facial paralysis, incoordination, hyperkinesia, paresthesia, hypoesthesia, hypertonia CV: chest pain, palpitations, vasodilation, syncope, hypertension, orthostatic hypotension, phlebitis, angina pectoris, arrhythmias EENT: amblyopia, refraction disorder, eye hemorrhage, glaucoma, dry eyes, hearing loss, tinnitus, parosmia, epistaxis, rhinitis, sinusitis, pharyngitis GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, enteritis, gastroenteritis, colitis, gastritis, esophagitis, eructation, biliary pain, duodenal ulcer, gastric ulcer, pancreatitis, cholestatic jaundice, tenesmus, melena, dysphagia, cheilitis, glossitis, stomatitis, dry mouth, ulcerative stomatitis, rectal and gum hemorrhage GU: decreased libido, sexual dysfunction, fibrocystic breasts, breast enlargement, metrorrhagia, epididymitis, abnormal ejaculation, urinary tract infection, hematuria, albuminuria, urinary frequency, urinary incontinence, urinary retention, urinary urgency, nocturia, cystitis, dysuria, renal calculus, nephritis, vaginal and uterine hemorrhage Hematologic: anemia, thrombocytopenia Hepatic: abnormal liver function tests, hepatitis Metabolic: gout Musculoskeletal: back pain, arthralgia, myalgia, myositis, myasthenia, arthritis, neck rigidity, leg cramps, bursitis, tenosynovitis, tendon contracture Respiratory: bronchitis, pneumonia, dyspnea, asthma Skin: rash, pruritus, contact dermatitis, alopecia, dry skin, acne, urticaria, eczema, seborrhea, skin ulcer, ecchymosis, petechiae, photosensitivity Other: taste loss or alteration; appetite changes; weight gain; infection; lymphadenopathy; accidental injury; flulike syndrome; peripheral, facial, or generalized edema; allergic reaction Interactions InteractionsDrug-drug. Antacids, colestipol: decreased atorvastatin level Azole antifungals, cyclosporine, erythromycin, fibric acid derivatives, niacin, other HMG-CoA inhibitors: increased myopathy risk Beta-adrenergic blockers: increased risk of adverse effects (amlodipine component) Cimetidine, ketoconazole, spironolactone: decreased levels or activity of endogenous steroids (atorvastatin component) Digoxin: increased digoxin level, increased risk of digoxin toxicity Fentanyl, nitrates, other antihypertensives, quinidine: additive hypotension (amlodipine component) Hormonal contraceptives: increased estrogen level Drug-diagnostic tests. ALT, AST, creatinine kinase: increased (atorvastatin component) Blood glucose: increased or decreased CBCs, platelets: decreased Drug-food. Grapefruit juice: increased drug level, greater risk of adverse effects Drug-herb. Red yeast rice: increased risk of adverse herbal effects Drug-behaviors. Acute alcohol ingestion: additive hypotension (amlodipine component) Patient monitoring• Monitor heart rate and rhythm and blood pressure, especially at start of therapy. Patient teaching• Tell patient drug may be taken with or without food. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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No references found | Tokyo, Aug 31, 2009 - (JCN) - Pfizer Japan and Astellas Pharma have reached a co-promotion agreement for a combination drug of hypertension treatment and hypercholesterolemia treatment, Caduet Combination Tablets, in Japan. The settlement will also entitle Ranbaxy to begin selling generic versions of Caduet -- a Pfizer drug that combines Lipitor with the company's Norvasc blood pressure treatment -- in the United States by November 2011. 7) Amlodipine is now found in combination drugs, such as Caduet (amlodipine with atorvastatin), and Lotrel (amlodipine with the ACE inhibitor benazepril), to help improve compliance for patients with several types of cardiovascular problems. |
Caduet |
CADTS CADU CADUBI Caducary Caducea Caducea Caducea caducean caducean caducean caducei caducei caducei Caducesus Caducesus Caducesus caduceus caduceus caduceus Caducibranchiate caducicorn caducity caducity caducous caducous caducus Caducus morbus Caducus morbus Caducus morbus Caducus morbus Caduet CadukeCaduseus Caduseus Caduseus Cadushis Cadushis Cadushis Cadushus Cadushus Cadushus Cadusis Cadusis Cadusis CADV CADVC CADVNC Cadw Cadwalader Cadwalader Cadwalader, Wickersham & Taft cadwaladerite Cadwaladr Cadwaladr ap Cadwallon Cadwaladr ap Cadwallon of Gwynedd Cadwaladr Fendigaid Cadwaladr Fendigaid ap Cadwallon Cadwaladr Fendigiad ap Cadwallon Cadwaldre Cadwallader, Rev. Mr. CADWES | |||||||
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