Cache Valley virus

Cache Valley virus

A negative-sense, single-stranded RNA virus of the Bunyaviridae family, genus Orthobunyavirus, Bunyamwera virus group serotype, which was first isolated in Utah and has been found in the rest of the US, especially the Midwest. It is mosquito-borne and causes outbreaks of spontaneous abortion, congenital malformations—e.g., musculoskeletal and CNS defects in sheep during lambing season. It may rarely infect humans, causing severe encephalitis and multiorgan failure.

Vector
Mosquitos—genera Culiseta, Aedes, Anopheles.

Cache Valley virus

Virology A common Bunyamwera virus, isolated in Utah in 1956 and recovered primarily from mosquitos–genera Culiseta, Aedes, Anopheles, and occasionally from vertebrates; in livestock, CVS may cause congenital malformations–musculoskeletal and CNS defects Clinical Rare in humans; CVS infection may be linked to severe encephalitis and multiorgan failure. See Bunyavirus, Encephalitis.

Cache Valley virus

one of the California serotype bunyaviruses associated with equine viral encephalomyelitis.
References in periodicals archive ?
Serological evidence of California group and Cache Valley virus infection in Minnesota white-tailed deer.
Cache Valley virus and California serogroup viruses) are distantly related and have [approximately equal to] 11% amino acid sequence homology to SFTSV.
The virus was found to belong to the Bunyamwera serogroup (genus Orthobunyavirus) by ELISA and identified as Cache Valley virus by PCR and sequencing (28).
We previously reported the isolation of Cache Valley virus (CVV), Kairi virus (KRIV), Cholul virus (CHLV), and South River virus (SOURV) from mosquitoes in the Yucatan Peninsula of Mexico (1-3).
Mice exposed to uninfected mosquitoes and injected at the feeding site with Cache Valley virus develop enhanced viremia and seroconversion compared with unbitten mice or to those co-injected with virus and mosquito saliva (20).
Mosquito feeding-induced enhancement of Cache Valley virus (Bunyaviridae) infection in mice.
We document the second known case of Cache Valley virus disease in a human.
Cache Valley virus (CVV), a mosquitoborne member of the Bunyamwera serogroup, family Bunyaviridae, genus Orthobunyavirus, is geographically widespread in North America, where it circulates between mosquitoes and mammals (1).
Isolation of Cache Valley virus and detection of antibody for selected arboviruses in Michigan horses in 1980.
In the case of vaccines manufactured in calves, the agents of concern include several bovine viruses (bovine viral diarrhea virus, bovine parainfluenza virus type 3, bovine respiratory syncytial virus, bovine adenoviruses, bovine parvovirus[es], bovine herpesvirus 1 [infectious bovine rhinotracheitis virus], other bovine herpesviruses, bovine reovirus[es], rabies virus, bluetongue viruses, bovine polyoma virus, bovine circovirus, Cache Valley virus, and orthopoxviruses other than vaccinia [such as cowpox]).