CAMK1

(redirected from CaM kinase I)

CAMK1

A gene on chromosome 3p25.3 that encodes the alpha subunit of a calcium/calmodulin-dependent protein kinase, which is part of the calcium-triggered CaMKK-CaMK1 signalling cascade and, upon calcium influx, regulates transcription activation, cell cycling, hormone production, cell differentiation, actin filament organisation and neurite outgrowth.
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In hypoxia-ischemia, CaM kinase is over-activated, but hypothermia has been shown to decrease this enzyme's activation.
For the study, researchers used rabbit heart cells, which behave much like human heart cells, and demonstrated that if CaM kinase is prevented from interacting with a protein that regulates calcium channels, negative effects, including cell death, do not occur.