(cyclophosphamide, vincristine, adriamycin, and dimethyl triazeno imidazole carboxamide) and James (cyclophosphamide and vincristine) regimens have been administered to adults, but these protocols have not been analyzed because of limited data.
Combination chemotherapy with various drugs such as CYVADIC
therapy  was also performed, but effective chemotherapy for leiomyosarcoma has not been standardized.
9 One patient had clinical stage III disease and received additional CYVADIC
(cyclophosphamide, vincristine, adriamycin, decarbazine) chemotherapy.