CYP3A4

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CYP3A4

A gene on chromosome 7q21.1 that encodes a member of the cytochrome P450 superfamily of monooxygenases, which catalyse reactions in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 localises to the endoplasmic reticulum; its expression is induced by glucocorticoids and drugs. It metabolises roughly half of the drugs in current use today—e.g., paracetamol (acetaminophen), codeine, cyclosporin A, diazepam and erythromycin—as well as steroids and carcinogens.

CYP3A4

One isoenzyme form of the cytochrome P450 system involved in the metabolism of many drugs. Drugs that alter this enzyme system can influence the metabolism of other agents taken by patients and cause unanticipated toxic effects.
References in periodicals archive ?
CYP3A Inhibitors - Avoid co-administration with strong and moderate CYP3A inhibitors.
On the other hand, the metabolism of schisandrin A, schisandrol A and schisandrol B was significantly inhibited in the presence of the typical CYP3A inhibitor ketoconazole in rCYP3A4 (Table 3) and rCYP3A5 (Table 4) incubation system, indicating that schisandrin A, schisandrol A and schisandrol B were the substrate of CYP3A4 and CYP3A5.
CAM is a potent CYP3A inhibitor, thus coadministration of tacrolimus and CAM leads to a pharmacokinetic interaction.
Reduced drug elimination can result from hepatic and renal insufficiency, decreased hepatic perfusion (7), altered tissue binding properties and drug-drug interactions known to inhibit the CYP3A enzyme, for instance cimetidine, azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, telithromycin and verapamil.
There are subgroups of patients who may react more strongly to CYP3A inducers, and they may be at a greater risk for an adverse interaction between St.
GENE POLYMORPHISM | Positive Selection at the Human CYP3A Locus
Drug interactions: Dronedarone is metabolized by the CYP3A system and is a moderate inhibitor of CYP3A and CYP2D6; therefore, it is possible that dronedarone can interact with drugs that are substrates of CYP3A and CYP2D6.
Ritonavir, simetidine, ketokanozole, eritromisin gibi guclu CYP3A inhibitorleri sildenafil ve tadalafilin plazma konsantrasyonlanni arttiracagmdan birlikte kullanimmdan kacinilmahdir.
16) The primary elimination pathway for nevirapine is oxidative metabolism by cytochrome P-450 enzymes of the CYP3A family, although CYP2B6 enzymes contribute as well.
7] Nonstandard abbreviations: SRL, sirolimus; CYP3A, cytochrome P450 3A; P-gp, P-glycoprotein; CNI, calcineurin inhibitor; SNP, single-nucleotide polymorphism; POR: P450 oxydo-reductase; [C.
The cells that line our small intestines contain an enzyme system called CYP3A, which metabolizes some drugs before they're absorbed into the bloodstream, explains David Greenblatt, professor of pharmacology and experimental therapeutics at the Tufts University School of Medicine.