Inhibitors - Avoid co-administration with strong and moderate CYP3A
Do not give VIEKIRAX with certain drugs that are sensitive CYP3A
substrates or strong inhibitors of CYP3A
On the other hand, the metabolism of schisandrin A, schisandrol A and schisandrol B was significantly inhibited in the presence of the typical CYP3A
inhibitor ketoconazole in rCYP3A4 (Table 3) and rCYP3A5 (Table 4) incubation system, indicating that schisandrin A, schisandrol A and schisandrol B were the substrate of CYP3A
4 and CYP3A
CAM is a potent CYP3A
inhibitor, thus coadministration of tacrolimus and CAM leads to a pharmacokinetic interaction.
Reduced drug elimination can result from hepatic and renal insufficiency, decreased hepatic perfusion (7), altered tissue binding properties and drug-drug interactions known to inhibit the CYP3A
enzyme, for instance cimetidine, azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, telithromycin and verapamil.
There are subgroups of patients who may react more strongly to CYP3A
inducers, and they may be at a greater risk for an adverse interaction between St.
GENE POLYMORPHISM | Positive Selection at the Human CYP3A
Drug interactions: Dronedarone is metabolized by the CYP3A
system and is a moderate inhibitor of CYP3A
and CYP2D6; therefore, it is possible that dronedarone can interact with drugs that are substrates of CYP3A
Ritonavir, simetidine, ketokanozole, eritromisin gibi guclu CYP3A
inhibitorleri sildenafil ve tadalafilin plazma konsantrasyonlanni arttiracagmdan birlikte kullanimmdan kacinilmahdir.
16) The primary elimination pathway for nevirapine is oxidative metabolism by cytochrome P-450 enzymes of the CYP3A
family, although CYP2B6 enzymes contribute as well.
7] Nonstandard abbreviations: SRL, sirolimus; CYP3A
, cytochrome P450 3A; P-gp, P-glycoprotein; CNI, calcineurin inhibitor; SNP, single-nucleotide polymorphism; POR: P450 oxydo-reductase; [C.
The cells that line our small intestines contain an enzyme system called CYP3A
, which metabolizes some drugs before they're absorbed into the bloodstream, explains David Greenblatt, professor of pharmacology and experimental therapeutics at the Tufts University School of Medicine.