PPIG

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PPIG

A gene on chromosome 2q31.1 that encodes peptidylprolyl cis-trans isomerase G (cyclophilin G), which, as with other PPIs, accelerates protein folding. It catalyses the cis-trans isomerisation of proline-imidic peptide bonds in oligopeptides. It may play a role in folding, transport and assembly of proteins, as well as in regulating pre-mRNA splicing.
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Wang and Hoffman's group combined work at the computer and at the bench to accurately assemble the mouse Cyp2 cluster, located on chromosome 7, and to compare it with the CYP2 cluster on human chromosome 19.
Coupled with the group's similar work with the related human CYP2 gene cluster, the mouse mapping data show how although not why the two species have expanded their CYP2 genes in the time since evolution separated them.
Detailed physical mapping using genomic clones proved to be an extremely fruitful approach for understanding one human gene cluster, the CYP2 cluster on chromosome 19 (Hoffman et al.
Specific exons and introns of CYP2 genes (see Supplemental Material) were then PCR-amplified from clone DNAs and sequenced.
Three CYP gene families, designated CYP1, CYP2, and CYP3, encode the cytochrome P450 enzymes that play the major role in human xenobiotic metabolism (Table 2) [7,10,35].
Cytochrome P450 Gene family isoenzymes Representative substrates CYP1 P450IA2 Caffeine, theophylline CYP2 P450IIC19 Mephenytoin, phenylbutazone P450IID6 Debrisoquin, metoprolol P450IIE1 Ethanol, acetaminophen CYP3 P450IIIA4 Erythromycin, cyclosporine Table 3.