CYP19A1


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CYP19A1

A gene on chromosome 15q21.1 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP19A1 localises to the endoplasmic reticulum and catalyses the last steps of oestrogen biosynthesis—three successive hydroxylations of the A ring of androgens.

Molecular pathology
CYP19A1 mutations can up- or downregulate aromatase activity.
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CYP19A1 genetic polymorphisms may be associated with obesity-related phenotypes in Chinese women.
CYP1A1, CYP19A1, CYP3A4, and COMT are involved in the synthetic pathway of estrogen and testosterone; NR1I2 (PXR, pregnane X receptor) and NR1I3 (CAR, constitutive androstane receptor) regulate the transcription of cytochrome P450s, such as CYP3A4, CYP2Cs, and CYP2B6 (Wang and LeCluyse 2003; Willson and Kliewer 2002).
sup][53] The combination of the TTTA long repeats and the minor alleles of rs10046 in CYP19A1 and rs2077647 in estrogen receptor (ESR)-alpha was a high risk for PCa despite isoflavones intakes.
We further tested this approach by implementing H-ARMS-PCR in the genotyping of 2 polymorphisms that are 142 bp apart in the 3' untranslated region (UTR) of the CYP19A1 gene (cytochrome P450, family 19, subfamily A, polypeptide 1): rs10046 (C>T) and rs4646 (G>T).
A recent study linked polymorphism of CYP19A1 to endometriosis.
ToxCast MIE linked to reproductive toxicity in fish (a) Prochloraz (b) Inhibition of CYP19A1 and AR binding Propiconazole (c) Inhibition of CYP19A1 Bisphenol A (d) Interacted with ER and also with the AR at higher concentrations Fenarimol (b) None Vinclozolin (e) None Fipronil (f) None Prometon (g) None Methoxychlor (h) None Atraziney (i,j) None In vivo, female fathead minnows Plasma E2 Prochloraz (b) Sig [down arrow], 0.
CYP: CYP1A1, CYP1A2, CYP2B7, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP2J2, CYP4A11, CYP4F2, CYP7A1, CYP7B1, CYP8B1, CYP11A1, CYP17A1, CYP19A1, CYP24A1, CYP26A1, CYP26B1, CYP27B1, CYP39A1.
400-0905) was conducted using recombinant human CYP19A1 enzyme with a substrate (Di(benzyloxymethoxy)fluorescein) concentration of 2.