CYP19A1

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CYP19A1

A gene on chromosome 15q21.1 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP19A1 localises to the endoplasmic reticulum and catalyses the last steps of oestrogen biosynthesis—three successive hydroxylations of the A ring of androgens.

Molecular pathology
CYP19A1 mutations can up- or downregulate aromatase activity.
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In contrast to human pregnancy, the rodent placenta does not synthesize estrogens because it does not express CYP19 or display aromatase activity (Malassine et al.
The aromatase enzyme, CYP19, a key enzyme in the conversion of androgens to estrogens.
Polymorphisms in the CYP19 (aromatase) gene also may result in less-than-expected efficacy of AIs (Cancer Res.
Rather, precursors of estrogen (testosterone and androstenedione) are produced by the adrenal gland and converted in peripheral tissue to estradiol and estrone via aromatization as a result of enzymatic products of the gene CYP19.
Moreover, polymorphisms in the CYP19 (aromatase) gene also may result in less-than-expected efficacy of AIs (Cancer Res.
In vitro studies have shown that hypoxoside induces the transporter protein, p-glycoprotein (P-gp) in Caco-2 cells, and stigmasterol, which is a constituent of AP, and rooperol both exhibited high inhibition of CYP3A4, 3A5 and CYP19 enzymes.
A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotype-tagging approaches.
One SNP has been shown in vitro to reduce affinity of the aromatase enzyme for exemestane [58]; however, there is no clinical evidence to date that genetic variations in CYP19 lead to resistance to aromatase inhibition in vivo.
work mainly focused on the epigenetic gene regulation of an important fertility gene, CYP19 gene, during folliculogenesis and lutenization in buffalo ovary.
CYP1A1, CYP19, and GSTM1 polymorphisms increase the risk of endometriosis.