CYP17A1


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CYP17A1

A gene on chromosome 10q24.3 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP17A1 localises to the endoplasmic reticulum and has 17 alpha-hydroxylase and 17, 20-lyase activities; it is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens and oestrogens.

Molecular pathology
CYP17A1 mutations are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17, 20-lyase deficiency, pseudohermaphroditism and adrenal hyperplasia.
References in periodicals archive ?
Anticancer activity of the selective CYP17A1 inhibitor, VT-464, in preclinical models of castrate-resistant prostate cancer.
Pioglitazone(Pio) Rosiglitazone(Posi) Gene Fold Fold Symbol Change p-value Change p-value CYP17A1 CYP1A1 17.
Out of these, only two, CYP17A1 (cytochrome P450, family 17, subfamily A) and MTHFR, are previously studied candidate genes, while others include previously largely unsuspected but plausible biologic candidates genes whose role in blood pressure regulation still needs to be confirmed.
The study will enroll men with progressive metastatic CRPC who have received up to two prior chemotherapy regimens; patients who have received prior MET or VEGFR inhibitors or prior CYP17A1 inhibitor therapy are not eligible to participate (although prior ketoconazole therapy is allowed if treatment was completed more than 120 days prior to study entry).
Total Tag SNPs Gene inclusion tag passing Gene SNPs inclusion criteria criteria AHRR 27 24 AIP/ARA9/XAP2 2 0 ARNT 5 4 Canonical AhR AhR 11 8 HSP90 6 4 p23/TGES3 4 4 ARNTL 19 14 CCNT1 3 3 DAP3 3 1 ESR1/ER-a 49 33 GTF2F1 3 1 GTF2F2 9 6 HIF1A/MOP1 6 2 NCOA1/SRC1/RIP160 11 6 NCOA2/SRC2 19 14 NEDD8 4 4 NR2F1 2 2 AhR interacting genes (Entrez Gene) NRIP1/RIP140 10 8 RB1 4 4 RELA/NFKB3 4 2 SMARCA4 10 6 SP1 4 4 SRC 14 10 TAF4 6 4 TAF6 6 4 TBP 6 3 XPO1 5 5 AR 2 0 CREB1 4 3 ERB/ESR2 16 12 GR/NR3C1 18 15 GSTCD 5 5 AhR interacting genes (STRING) GSTM1 1 0 MYC 6 5 PPARA 16 11 RELB 6 4 UGT1A5 16 10 CYP1A1 2 1 CYP1A2 2 1 Dioxin-induced genes CYP1B1 6 5 TP53 5 1 ARNT2 58 36 Genes associated with reproductive CYP17A1 6 4 outcomes: Sone and Yonemoto 2008 9q31.
It blocks the formation of testosterone by inhibiting CYP17A1, an enzyme involved in the formation of testosterone that can occur at the site of metastatic tumor lesions.
6] Human genes: KLK3, kallikrein-related peptidase 3; AR, androgen receptor; CYP17A1, cytochrome P450, family 17, subfamily A, polypeptide 1; CDKN2A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); CDH1, cadherin 1, type 1, E-cadherin (epithelial); CD44, CD44 molecule (Indian blood group); MGMT, O-6-methylguanine-DNA methyltransferase; RASSF1A, Ras association (RalGDS/AF-6) domain family member 1; ABCB1, ATP-binding cassette, sub-family B (MDR/TAP), member 1; APC, adenomatous polyposis coli; GSTP1, glutathione S-transferase pi 1; BCL2, B-cell CLL/lymphoma 2; PTEN, phosphatase and tensin homolog.
CYP: CYP1A1, CYP1A2, CYP2B7, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP2J2, CYP4A11, CYP4F2, CYP7A1, CYP7B1, CYP8B1, CYP11A1, CYP17A1, CYP19A1, CYP24A1, CYP26A1, CYP26B1, CYP27B1, CYP39A1.