4,8,12,13] Six major classes of CYP isoenzymes that play a vital role in drug biotransformation are CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, CYP 2E1, and CYP 3A4.
The crude extract of this plant inhibits metabolic isoenzyme CYP 2E1 in mouse and human.
There are experimental data showing that dry extract from Silybum marianum significantly inhibited a number of CYPs including CYP 3A4 and CYP 2E1 (Doehmer et al.
Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride.
el CYP 2E1 y el CYP 1A1 estan presentes en la especie humana, rata, raton, hamster y otros mamiferos (Anzenbacher y Anzenbacherova, 2001; Shimada y Fujii-Kuriyama, 2004) y otros son caracteristicos de una especie en particular (p.
Ademas, el CYP 2E1 es el principal citocromo que cataliza el metabolismo de las N- nitrosodialquilaminas de cadena alquilo corta, como es el caso de la NDMA (Kushida et al.
The
CYP 2E1 pathway has low initial catalytic efficiency compared with the ADH/ALDH pathway, but it may metabolize alcohol up to 10 times faster after chronic alcohol consumption or cigarette smoking and accounts for metabolic tolerance.
El objetivo de este estudio fue comparar el efecto del consumo moderado de vino tinto sobre la expresion y la actividad del CYP 2E1 en higado y rinon de rata.
3) Numerosos estudios indican que el consumo cronico de etanol aumenta la actividad de diversas especies del CYP, en particular de la isoenzima CYP 2E1.
Huh7 cells were transfected with NS5A-expressing constructs and subjected to quantification of
CYP 2E1 levels by real-time RT-PCR (a) or Western blotting (b) 40 hrs after transfection.
Rabbit polyclonal antibody
CYP 2E1 and HO-1 was provided by Santa Cruz (California.
5 [micro]M Source Sigma- Sigma- Aldrich Aldrich Incubation time 45 min 45 min Excitation wavelength 410 390 Emission wavelength 460 460
CYP 2E1 3A4 Amount Enzyme/ 2.
