CYP 2C9

CYP 2C9

microsomal enzyme responsible for the oxidation of S-warfarin, phenytoin, and numerous NSAIDs. Inhibitors include azole antifungals (for example, ketoconazole, itraconazole, metronidazole); induced by rifampin.

CYP 2C9

Abbreviation for a microsomal enzyme responsible for the oxidation of S-warfarin, phenytoin, and numerous nonsteroidal antiinflammatory drugs. Inhibitors include azole antifungals (e.g., ketoconazole, itraconazole, metronidazole); induced by rifampin.
References in periodicals archive ?
In humans, (S)-warfarin is metabolized almost exclusively by CYP 2C9 to its inactive form, (S)-7-hydroxywarfarin, while (R)-warfarin is metabolized by multiple CYPs such as CYP1A1 and CYP3A4 (Kaminsky and Zhang 1997).
The AutoGenomics platform enables the rapid testing of such CYP 450 tests including CYP 2C9, CYP 3A4 & CYP 3A5 that have been quoted in recent publications as factors that could be of interest in drug dosing" said Ramanath Vairavan, Senior Vice President at AutoGenomics.
Multiple regression analysis for modeling warfarin daily dose requirements based on age, sex, weight, VKORC1 (-1639G>A), and CYP 2C9 genotypes.
Assessment of the gene coding for CYP 2C9 can help physicians tailor warfarin doses to prevent bleeding episodes in patients with genetic propensities for higher-than-average responsiveness to the drug.