CYP 1A2

CYP 1A2

microsomal enzyme, the substrates of which include theophylline, antidepressants, and tacrine. It is inhibited by grapefruit juice and quinolones, and induced by smoking, phenobarbital, phenytoin, rifampin, and omeprazole.

CYP 1A2

A microsomal enzyme, the substrates of which include theophylline, antidepressants, and tacrine. It is inhibited by grapefruit juice and quinolones, and induced by smoking, phenobarbital, phenytoin, rifampin, and omeprazole.
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CYP 1A2 (IF/IF) and caffeine (HBP, Ml, CHD, tachycardia, stiff aorta, PWV, Al, SBP, PP, vascular inflammation, increased catecholamines)
Organovo has previously shown that exVive3D Liver Models produce important liver proteins including albumin, fibrinogen and transferrin, synthesize cholesterol, and possess inducible cytochrome P450 enzymatic activities, including CYP 1A2 and CYP 3A4.
Therefore, the aim of this study was to investigate the effects of MA on the CYP 1A2, 2C9/11, 2D1/6, 2E1 and 3A2/4 activities by human and rat liver microsomes and specific CYP isoforms.
Stable albumin production for over 40 days, fibrinogen and transferrin production, and inducible cytochrome P450 enzymatic activities, including CYP 1A2 and CYP 3A4;
These novel 3D liver tissues possessed critical liver functions, including albumin production, fibrinogen and transferrin production, and inducible cytochrome P450 enzymatic activities, including CYP 1A2 and CYP 3A4.
Interactions may occur when Rilutek is given concurrently with agents that affect hepatic CYP 1A2 activity.