CYP


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CYP

Abbreviation for cytochrome P450 enzymes; usually followed by an arabic numeral, a letter, and another arabic numeral (for example, CYP 2D6). These enzymes are found in and on the smooth endoplasmic reticulum of liver and other cells and are responsible for a large number of drug biotransformation reactions.

CYP

Abbreviation for cytochrome P-450 enzymes; usually followed by an arabic numeral, a letter, and another arabic numeral (e.g., CYP 2D6). These enzymes are found in and on the smooth endoplasmic reticulum of liver and other cells and are responsible for a large number of drug biotransformation reactions.

couple-year of protection

,

CYP

In family planning, the number of days per year that any method of birth control will prevent conception. Abstinence from sexual intercourse, or sterilization of both members of a couple, provides absolute (365 days/year) protection. Other methods of family planning or fertility inhibition are relatively less effective. Couples that attempt penile withdrawal before male climax (coitus interruptus) have the lowest levels of CYP of any method. Condoms provide a moderate increase in contraceptive effectiveness but are less effective than intrauterine devices, contraceptive pills, or contraceptive implants.

cytochrome

(si'to-krom) [? + chroma, color]
An iron-containing protein found in the mitochondria of eukaryotic cells; each is given a letter name (a, b, c). The cytochrome transport system (electron transport chain) is the last stage in aerobic cell respiration. See: cytochrome oxidase; cytochrome P450; cytochrome transport system

cytochrome P450

Abbreviation: CYP
A group of enzymes present in every type of cell in the body except red blood cells and skeletal muscle cells. They are important in metabolizing substances normally present in the body such as steroids, fat-soluble vitamins, fatty acids, prostaglandins, and alkaloids. The P450 enzymes also detoxify drugs and a great number of environmental pollutants, such as carcinogens present in tobacco smoke and charcoal-broiled meat, polychlorinated biphenyls, and dioxin. Specialized types of cytochrome P450 are involved in the synthesis of nitric oxide.

cytochrome P450

Abbreviation: CYP
A group of enzymes present in every type of cell in the body except red blood cells and skeletal muscle cells. They are important in metabolizing substances normally present in the body such as steroids, fat-soluble vitamins, fatty acids, prostaglandins, and alkaloids. The P450 enzymes also detoxify drugs and a great number of environmental pollutants, such as carcinogens present in tobacco smoke and charcoal-broiled meat, polychlorinated biphenyls, and dioxin. Specialized types of cytochrome P450 are involved in the synthesis of nitric oxide.
See also: cytochrome
References in periodicals archive ?
This study investigated the effects of on the metabolism of probe substrates of human CYP isoforms including CYP1A2, CYP2C9, and CYP3A4, the major isoforms that are responsible for the metabolism of warfarin to assess the potential interactions of Danshen with drugs that utilize these isoforms for their biotransformation and CYP2E1 which is important in the metabolism of a variety of xenobiotics and pro-carcinogens.
After an inducer is discontinued, transcription returns to basal levels within 18 hours; however, the degradation of CYP proteins is a first-order process, with a half-life of 8 to 30 hours.
The attractive cost effectiveness of mobile clinics may have less to do with their mobility and more to do with the attractive pricing of long acting methods which allowed mobile clinics to achieve higher CYP coverage.
Chlorphenamine also inhibits isoenzyme CYP 2D6 responsible for the biotransformation of dextromethorphan; when the two drugs are combined together, the patient is likely to experience serotonin syndrome.
In previous studies, lignans containing the methylenedioxyphenyl moiety showed inhibition of CYP activity (Lee et al.
After 96 h of acclimatization fish in the treatment group were exposed to acute concentration 63 g L-1 (LC50 of 96 h) of CYP while the control group received 80% acetone equal to the volume used for exposing CYP in the treatment group.
The CYP was recently donated a new kit from The Rise in Scotswood, Newcastle a PS265m redevelopment programme by the New Tyne West Devel T -opment Company, bringing 1,800 new homes, business and community facilities to the area.
England CYP manager Alan Watson, who handed Carrick his England cap in 1997, said: "The Clubs for Young People - formerly known as Boys' Clubs - have provided a springboard for a number of top-flight stars.
After statistical adjustment for age, socioeconomic status, comorbidity, use of other CYP 2D6 drugs, and timing and duration of tamoxifen therapy, investigators found that the breast cancer mortality risk was increased 24% among women who were coprescribed paroxetine during 25% of their tamoxifen treatment.
Consequently, the knowledge and confidence gained during involvement with CYP is transformed into the workplace and in dealings with our clients.