CCR8

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CCR8

A gene on chromosome 3p22 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR8 is preferentially expresses in the thymus; its ligands include thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 (MIP-1) beta. CCR8 is thought to have a central role in regulating monocyte chemotaxis and thymic cell apoptosis, and it may also contribute to positioning of activated T cells within antigenic challenge sites and specialised areas of lymphoid tissues.