CXCR6

CXCR6

A gene on chromosome 3p21 that encodes a member of the G protein-coupled receptor family which is a receptor for chemokine CXCL16 and a coreceptor for strains of HIV-2 and m-tropic HIV-1.
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The low-frequency ARGs that correlated with canonical variables include DEFB1 with C4, KIR with C7, HLA-A with C5, CCL11 with C7, LY6D with C4, APOBEC3B with C5, and CXCR6 with C6.
6] While most HIV-1 variants use CCR5 and CXCR4 as the main co-receptor in vivo, up to 12 other chemokine co-receptors (including CCR2b, CXCR6 and GPR1) for HIV infection have been identified in vitro.
HIV-1 and HIV-2 strains have been reported to be capable of utilising several alternative chemokine receptors, including CCR2b, CXCR4, CXCR6 and GPR1, to mediate infection of cells.
Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans.
Additional genes of importance include CXCR6, prospero homeobox 1 (PROX1), an intergenic SNP between ribosomal protein S6 kinase alpha-6 (RPS6KA6) and cylicin-1 (CYLC1) genes (X chromosome).
CXCR6 is expressed in human prostate cancer in vivo and is involved in the in vitro invasion of PC3 and LNCap cells.