CXCR4


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Related to CXCR4: CCR5

CXCR4

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds specifically to stromal cell-derived factor-1, transducing a signal by increasing intracellular calcium ions and enhancing MAPK1/MAPK3 activation. It acts as a receptor for extracellular ubiquitin, is involved in haematopoiesis and in cardiac ventricular septum formation, plays a role in gastrointestinal tract vascularisation by regulating vascular branching and/or remodelling in endothelial cells, may be involved in cerebellar development and, in the CNS, may mediate hippocampal-neuron survival.

Molecular pathology
CXCR4 acts with the CD4 to support HIV entry into cells; it is highly expressed in breast cancer cells. CXCR4 mutations cause WHIM (warts, hypogammaglobulinaemia, infections, and myelokathexis) syndrome.
References in periodicals archive ?
This was a surprise, because the main thing CXCR4 has been known for is its role in forming the brain, not healing the brain," Klein says.
The data will include results from initial targets that include CXCR4 and CD-20.
Trofile is a patient selection co-receptor tropism assay that determines whether a patient is infected with a strain of HIV that uses either the CCR5 coreceptor, the CXCR4 coreceptor, or a combination of CCR5 and CXCR4 to enter cells.
R5" variants use the CCR5 co-receptor, "X4" viruses use the CXCR4 co-receptor, and dual/mixed HIV uses both co-receptors.
Determining the co-receptor that a HIV strain uses, either CCR5, CXCR4 or a combination of both, is a critical component of monitoring and treating HIV.
SAN DIEGO -- Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) announced today that it has transferred exclusive license rights to Proximagen Limited (AIM: PRX) for a series of compound hits related to the CXCR4 target with application for a number of indications including those related to the central nervous system.
Viruses that use CCR5 are called R5-tropic ("R5") and those that use CXCR4 are called X4-tropic ("X4").
In contrast, HIV-1 IIIB is a CXCR4-tropic virus that infects cells expressing the human receptor CXCR4 in addition to the receptor CD4.
To date, the T4-L method has been successfully applied to solve at least nine novelGPCR structures, including the beta 2 adrenergic receptor, the D3 dopamine receptor, the CXCR4 receptor, the H1 histamine receptor, the S1P1 receptor and the A2A adenosine receptor, which have been reported in Science and Nature.
Its product portfolio includes POL6326, a CXCR4 antagonist, currently in Phase II trials for stem cell transplant in multiple myeloma patients, POL7080 a highly specific antibiotic with a novel mechanism of action and several preclinical PEMdrug candidates targeting lung and skin diseases as well as indications related to inflammation and cancer.
Data were also presented from Sangamo's ZFN gene-modification program to generate CD4 T-cells that are resistant to so-called "X4-tropic" strains of HIV, strains of HIV that use the CXCR4 co-receptor to infect cells and are characteristic of late-stage HIV infections.
announced today the presentation of Phase I and preclinical data for TG-0054, the Company's chemokine receptor CXCR4 antagonist and a novel, potent stem cell mobilizer, at the ASH Annual Meeting held in New Orleans, the US, from December 5 to 8, 2009.