CXCR2

CXCR2

A gene on chromosome 2q35 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which selectively binds IL8, as well as CXCL1, CXCL3, GRO/MGSA and NAP-2. CXCR2 is a potent neutrophil chemotactic factor and mediates neutrophil migration to sites of inflammation; it mediates IL8’s angiogenic effects on intestinal microvascular endothelial cells.
References in periodicals archive ?
SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans.
Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death ofcells expressing CXCR2.
The researchers found that LukED latches onto surface receptors called CXCR1 and CXCR2, creating the same deadly pores that it does when it latches onto CCR5 receptors.
Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2.
Nonapical and cytoplasmic expression of interleukin, CXCR1, and CXCR2 correlates with cell proliferation and microvessel density in prostate can cer.
At the end of termination, the cell surface expression of CD16, CD69, CXCR2 and induction of apoptosis were analyzed using flow cytometry.
Four partnered programs are in active clinical trials: a CXCR2 antagonist for chronic obstructive pulmonary disease, p38 MAP kinase inhibitors for rheumatoid arthritis, an enzyme inhibitor for oncology and a candidate for metabolic diseases.
Blocking the IL-8 CXCR2 receptor may represent an important opportunity in treating certain inflammatory diseases.
The activity of PA401 was benchmarked against other relevant treatment modalities including the PDE4 inhibitor roflumilast and the CXCR2 antagonist SCH527123.
Low-Molecular Weight CXCR2 Antagonists as Promising Therapeutics
I found that by genetically knocking out CXCR2, we can reduce the amount of amyloid in various laboratory models and, by using drugs that specifically block the CXCR2 receptor, we are able to show that a decrease in production of amyloid can be achieved," said Dr.
CXCR2 is necessary for the development and persistence of chronic fungal asthma in mice.