CXCR1


Also found in: Encyclopedia.

CXCR1

A gene on chromosome 2q35 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which selectively binds IL8. IL8 binding activates neutrophils via a G protein-coupled receptor, which in turn activates the phosphatidylinositol-calcium second messenger system.
References in periodicals archive ?
The chemokine receptors CXCR1 and CXCR2 regulate oral cancer cell behaviour.
El basofilo expresa tambien los receptores de quimiocinas CCR1, CCR2, CXCR1, CXCR3, CXCR4 y de factores C3a y C5a del complemento; ademas, RANTES, MCP-8 y MCP-4 son factores quimiotacticos y en menor proporcion IL-8 y MCP-1.
Nonapical and cytoplasmic expression of interleukin, CXCR1, and CXCR2 correlates with cell proliferation and microvessel density in prostate can cer.
They have identified a receptor called, CXCR1, on the cancer stem cells, which triggers growth of stem cells in response to inflammation and tissue damage.
CXCR1 is a receptor for Interleukin-8, or IL-8, a protein produced during chronic inflammation and tissue injury.
low] Marcadores fenotipicos CD16 +++ CD56 - / + Receptores inhibidores KIR +++ NKG2A - / + CD94 - / + ILT-2 + Moleculas de adhesion CD2 + CD62L - / + CD44 + LFA-1 ++ Receptores de citoquinas y quimioquinas Alta afinidad IL-2 - Baja afinidad IL-2 ++ IL-1 - / + CCR7 - CXCR1 +++ CXCR3 - / + CX3CR1 +++ Subgrupo de celulas NK [CD16.