PF4

(redirected from CXCL4)

PF4

A gene on chromosome 4q12-q21 that encodes a protein released from the alpha-granules of activated platelets which binds with high affinity to heparin. PF4’s major physiologic role appears to be neutralisation of heparin-like molecules on the endothelial surface of blood vessels, inhibiting antithrombin-III activity and promoting coagulation; as a chemoattractant for neutrophils and fibroblasts, PF4 likely plays a role in inflammation and wound repair.
References in periodicals archive ?
Among these chemokines are CXCR4 and CXCL12, which are critical to the migration and attachment of cancer cells to the protective bone marrow environment as well as to metastatic sites, and CXCL4, which slows bone marrow recovery after chemotherapy.
Secondly, CXCL4 was found to be closely associated with disease severity and implicated in key immune defects that recapitulate SSc.
In laboratory studies, the protein, called CXCL4 or PF-4, binds to HIV such that it cannot attach to or enter a human cell.
CXCL4 belongs to a family of molecules called chemokines that help regulate the movement of immune cells around the body.
Immune complexes formed following the binding of anti-platelet 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion.
9:15 CXCL4 AND CXCL10 PREDICT RISK OF FATAL CEREBRAL MALARIA,
It has been shown in vitro that angiostatic factors, such as thrombospondin-1 and the chemokines CXCL4 and CXCL14, appear to enhance DC maturation and APC function.
PF4, also known as CXCL4, is a polypeptide constituent of platelet alpha granules that is released during platelet aggregation and inhibits heparin-mediated reactions.
today announced the publication of preclinical data showing that CT-2009 disrupts heteromers formed by the platelet-derived chemokines CCL5 (RANTES) and CXCL4, thereby preventing lung damage in multiple mouse models of acute lung injury (ALI).
at LMU showed that the platelet-derived chemokines CCL5 and CXCL4 form heteromers in lung tissue samples from human patients and mice with ALI, positively correlating with neutrophil influx into the tissue as well as changes in lung permeability.
9:15 CXCL4 AND CXCL10 PREDICT RISK OF FATAL CEREBRAL MALAR-IA, Nana Wilson * (1), Vidhan Jain (2), Christina Roberts * (3), Naomi Lucchi (3), Pradeep Joel5, Mrigendra P.
One of them (7765 Da) was subsequently identified as PF4, which is a CXCL4 chemokine expressed in various inflammation cell types (29) as well as metastatic prostate cancer cells (30) and megakaryoblastic leukemia cells (31).