CXCL2


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CXCL2

A gene on chromosome 4q13.3 that encodes a chemokine produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is thought to have a haematoregulatory role and suppresses haematopoietic progenitor cell proliferation.
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The microarray analysis was performed to evaluate the innate immunity and demonstrated that AG significantly induced the expression of cytokines, chemokines, and co-stimulatory receptors, such as IL-1[alpha], CXCL2, and CD69.
CCL3, CCL4, CCRL2, CXCL2 and CXCL10), as well as several co-stimulatory molecules (e.
Breast and prostate cancers are often associated with latent or chronic inflammatory reactions, and in both cases, the tumour cells were found to produce pro-inflammatory immunomodulators including the cytokines CXCL1 und CXCL2.
IL-17 acts mainly as a proinflammatory mediator through a variety of mechanisms including stimulation of the production of other proinflammatory cytokines such as TNF-[alpha], IL-1 and IL-6 as well as chemokines CXCL1 and CXCL2, induction of the expression of adhesion molecules such as ICAM-1, stimulation the production of C-reactive protein and nitric oxide (12, 13, 27, 28).
4] exposure, 7 genes (CCR7, CXCL2, CXCR4, IL15, IL8, PGKI, and TNFRSFIA) showed fold inductions significantly dif ferent from 0 using real-time PCR.
4] also induced expression of CCL11, CCL5, CCL3, and CXCL2, and BB exposure resulted in upregulation of CCL4.
Additionally there also were genes related to the CXC family of chemokines (MCP-1, IL-8, CXCL1, CXCL2, CXCL3, and CXCR4).