CXCL2


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CXCL2

A gene on chromosome 4q13.3 that encodes a chemokine produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is thought to have a haematoregulatory role and suppresses haematopoietic progenitor cell proliferation.
References in periodicals archive ?
Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2.
pylori-challenged mice with NF-[kappa]B decoy oligonucleotides did not reduce the gastric expression of Th1 chemokines as compared with mice treated with control scrambled oligonucleotides, although treatment with NF-[kappa]B decoy oligonucleotides did lead to a marked reduction in the expression of NF-[kappa]B-related genes such as TNF and CXCL2.
Moreover, these effects of IL-33 involve induction of IL-6, CXCR2 utilizing chemokines, such as CXCL1 and CXCL2, and secretion of type 2 cytokines (Barlow et al.
Chemokines, including CXCL2, CXCL8 (IL8), showed substantially higher expression in CTCs enriched with the Parsortix system.
Jeyaseelan, "CXCL1 regulates pulmonary host defense to Klebsiella infection via CXCL2, CXCL5, NF-[kappa]B, and MAPKs," Journal of Immunology, vol.
Nuestro analisis de expresion global con microarreglos revelo diferencias significativas en la expresion de quimiocinas CXCL- y CCL- tales como CXCL1 (Gro-[alfa]), CXCL2 (Gro-[beta]), CXCL5 (ENA-78), CXCL8 (IL-8) y CXCL10 (IP-10).
The microarray analysis was performed to evaluate the innate immunity and demonstrated that AG significantly induced the expression of cytokines, chemokines, and co-stimulatory receptors, such as IL-1[alpha], CXCL2, and CD69.
Breast and prostate cancers are often associated with latent or chronic inflammatory reactions, and in both cases, the tumour cells were found to produce pro-inflammatory immunomodulators including the cytokines CXCL1 und CXCL2.
A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis.
IL-17 acts mainly as a proinflammatory mediator through a variety of mechanisms including stimulation of the production of other proinflammatory cytokines such as TNF-[alpha], IL-1 and IL-6 as well as chemokines CXCL1 and CXCL2, induction of the expression of adhesion molecules such as ICAM-1, stimulation the production of C-reactive protein and nitric oxide (12, 13, 27, 28).
The effect of IL-17 on CXCL2 depends on IL-1[beta], which is also enhanced by IL-17.
CXCL2 also was significantly higher in wt mice following treatment with TCDD: approximately 450-fold in adipose, 68-fold in kidney, 74-fold in spleen, 6-fold in liver, and 5- and 3-fold in lung and thymus, respectively.