CXCL16


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CXCL16

A gene on chromosome 17p13 that encodes a protein that acts as a scavenger receptor on macrophages, specifically binding to oxLDL (oxidised low-density lipoprotein), suggesting that it may play a role atherogenesis. CXCL16 induces a brisk chemotactic response and mobilises calcium.
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These genes encoded cytokines (CSF3, CSF2, CCL3, TNF, CCR1, IL13, KIT, CCL5, CCL4, IL10, CXCL10, IL12RB2, IFNG, IL1B, IL1A, IL8, MET, CD40, HGF, LEP, CXCL16, CX3CR1, CCR2, PDGFRA, IL12B, IL2), lipid metabolism related genes (CD36, GPX4, LPIN1, LPL, LPB), transcription regulators (BCL3, FOS and NFKBIA), receptors (TNF, IL8, RELA, TLR1, TIRAP, TLR2, NFKBIA, NFKB1, TLR4, CD40, CCL5, CXCL10, FOS, JUN, MAP3K8, IL1B, LBP, IL12B, CD14, SPP1), and others such as SELP, SELL, and SOD1, all play a role in some aspect of the immune response including cytokine activity (IL10, TNF, IL8, and IL1B), cell adhesion (SELL and SELP), immune activation (CD14 and TLR2), acute phase reaction (TNF, IL1B, and SAA3), apoptosis (BCL2, BAX).
For example, CXC-chemokine ligand 16 (CXCL16) (a transmembrane CXC chemokine) knockout mice administrated with angiotensin II (Ang II) were found to have significantly less circulating fibrocytes in injured kidney compared with these in wild-type mice,[sup][61] indicating CXCL16 is one of the mediators involved in circulating fibrocyte recruitment.
Critical role of CXCL16 in hypertensive kidney injury and fibrosis.
Introduction of additional markers allowed for further characterization of these subsets indicating that CD14lowCD16+ monocytes expressed higher levels of CD43, CD115, CXCL16, CXCR1 and C3AR1 expression whereas CD14highCD16- monocytes exhibited higher levels of CD1d, CD93 and CD114.
To that end, Taichman said he was surprised at the large role played by the protein CXCL16 in altering the healing type cells in such a way that they revved the cancer cells into overdrive.
30) showed with the matrigel invasion assay that both CXCL12 and CXCL16 induced invasion with PC3 cell lines, but they did not report investigating the effects of CXCL9, CXCL1, or CXCL14.
These arrays have been featured in hundreds of publications, including research published in Nature (2008; 455; 391-395, Human PDGF-AA), Nature Medicine (2007; 13: 742-747, Mouse G-CSF), Proceedings of the National Academy of Sciences USA (2007; 104: 7438-7443, Mouse CXCL16, SDF-1), FASEB Journal (2009; 23: 351-361, Mouse SDF-1, SCF), and the Journal of Biological Chemistry (2007; 282: 34510-34524).
IL-18 accelerates atherosclerosis accompanied by elevation of INF- [gamma] and CXCL16 expression independently of T cells.
Six genes were selected for confirmation by real-time PCR, and of these, CXCL16, ZNF331, JUN, and PF4 were the most significantly affected by benzene exposure, a finding that was confirmed in a larger data set from 28 subjects.
Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling.
IL-18 accelerates atherosclerosis accompanied by elevation of IFN-gamma and CXCL16 expression independently of T cells.
In experiments with mouse tissues, the UCSF researchers determined that the novel chemokine, which they named CXCL16 (for 16th chemokine of the CXC subfamily) is produced by cells within the spleen and lymph nodes -- including the so-called dendritic cells which help trigger immune responses -- and also by cells in the spleen's red pulp.