CXCL12


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CXCL12

A gene on chromosome 10q11.1 that encodes a stromal cell-derived alpha chemokine of the intercrine family which, once bound to its receptor, CXCR4, activates lymphocytes, an interaction that has been implicated in the metastasis of breast and other cancers.

Molecular pathology
CXCL12 mutations are associated with resistance to HIV-1 infections.
References in periodicals archive ?
For example, no effect of KJ on CXCL12 and NAMPT genes expression can be predicted based on the sum of the effects of EPE and ESE.
Their work will focus on a single stem-cell recruitment factor found in connective tissue and bone cells, CXCL12 and its receptor, which they hypothesize play key roles in promoting osteogenesis, both in response to injury as well as mechanical stress.
Lyme disease has been associated with an increase in pro-inflammatory cytokines interleukin-6 (IL-6), IL-8, IL-12, IL-18 and interferon-gamma, and chemokines CXCL12 and CXCL13, along with increased levels of pro-inflammatory lipoproteins.
The research, led by Professor Douglas Fearon, determined that this barrier is created by a chemokine protein, CXCL12, which is produced by a specialised kind of connective tissue cell, called a carcinoma-associated fibroblast, or CAF.
People who have a version of the CXCL12 gene previously associated with inflammatory diseases also carry more Granulicatella bacteria on their skin.
The study also found that people with a version of CXCL12 gene also carry more Granulicatella bacteria, which are associated with inflammation.
1-7) SDF-1, also called CXCL12 (CXC chemokine ligand 12), appears as the sole ligand for CXCR4.
21 CXCL12 rs501120 early-onset 10q11 CXCL12 rs1746048 myocardial infarction MI 12q24 SH2B3 rs3184504 CAD 12q24.
CAFs are capable of secreting elevated levels of stromal cell-derived factor 1 (SDF-1), also called CXCL12, which plays a central role in the promotion of tumour growth and angiogenesis; CAF-derived SDF-1 not only stimulates carcinoma growth directly through the CXCR4 receptor expressed on tumour cells, but also serves to recruit endothelial progenitor cells into tumours [11,12].
CXCL12 is a multipotent ligand impacting cells in the neural, vascular and immune systems.
WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12.