CXCL11


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CXCL11

A gene on chromosome 4q21 that encodes a CXC-type chemokine that is chemotactic for IL-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. CXCL11 induces calcium release in activated T-cells, binds to CXCR3 and may play an important role in CNS diseases involving T-cell recruitment. It may also play a role in cutaneous immune responses.
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We identified 7 novel biomarkers as statistically significant in discriminating protein concentrations in blood from men with advanced prostate cancer compared to controls: APOC1, ASPN, COMP, CXCL11, CXCL9, F5, and PCSK6.
It is interesting that the chemokines CXCL9 and CXCL11 were found to be overexpressed in our laser-microdissected tissues and showed discrimination for advanced prostate cancer.
In established cutaneous LE lesions, the CXCR3 ligands CXCL9 (interferon-gamma [IFN[gamma]]-induced monokine), CXCL10 (IFN[gamma]-inducible protein 10), and CXCL11 (IFN-inducible T cell alpha chemoattractant) are the most abundantly expressed chemokine family members.
Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation.
Actimmune(R) stimulates the production of CXCL10 and CXCL11, two genes that have been shown to reduce pulmonary fibrosis in animal models.