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When CXCL10 was blocked, mice had lesser T cells, a greater parasite burden and actively reproducing parasites.
Neither compound affected the CXCL10 signal assay or produced an A[C.
The genes encoding chemokines (IL8, CXCL10, PF4, CCL3, and CXCL1) were expressed similarly in the 2 groups.
Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation.
By administering an effective dose of a specific neutralizing agent for chemokine CXCL10, and thus promoting the histological and functional repair of hepatic cells, we hope to offer a treatment that will improve the quality of life of patients who suffer from acute liver failure.
Targeted inflammatory mediators and cell types affected by the pluripotent mechanism of action of apremilast include: inhibition of production of TNF-a, IFN-g, IL-12, IL-23, IL-2, IL-5, IL-17, CXCL9 (MIG), CXCL10 (IP-10), CCL2 (MCP-1), CCL3 (MIP-1a), IL-8, LTB4, and iNOS; inhibition of activation of T and NK cells, monocytes, dendritic cells, synovial macrophages, neutrophils, chondrocytes, keratinocytes, and endothelial cells; as well as, the unique inhibition of joint pannus formation and cartilage erosion.
com)-- Mouse CCL4, CXCL9, and CXCL10 are important members of the chemokine family of proteins.
The M1 macrophages are induced by IFN-[gamma] and identified by expression of IL-12, tumor necrosis factor, and the chemokine CXCL10, and display a phenotype associated with tumor resistance, killing of intracellular parasites, and tissue destruction (see Table for definition and nomenclature of chemokines).
9:15 CXCL4 AND CXCL10 PREDICT RISK OF FATAL CEREBRAL MALAR-IA, Nana Wilson * (1), Vidhan Jain (2), Christina Roberts * (3), Naomi Lucchi (3), Pradeep Joel5, Mrigendra P.
Elevated interleukin-12 and CXCL10 in subacute sclerosing panencephalitis.
announced today positive safety data from two Phase 1 trials that support the Phase 2 clinical development program of MDX-1100, a fully human monoclonal antibody that targets CXCL10 (also known as IP-10), for the treatment of inflammatory diseases.
Expression analysis of the T-cell targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group.
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