CXCL1


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Related to CXCL1: CX3CL1, CXCL10, CXCL2, CXCL5

CXCL1

A gene on chromosome 4q21 that encodes a chemokine which, as a group, are involved in cell trafficking of leukocytes through interactions with 7-transmembrane and G protein-coupled receptors, and play critical roles in the development, homeostasis and function of the immune system. Chemokines are also involved in CNS and endothelial cell activity.
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Bacteria effect on gene expression of CXCL1, CCL5 and CXCL5: Significant upregulation of gene expression for CXCL1 was noted in response to S.
The present studies show that several bacterial pathogens induced IL-8 secretion and activation of CXCL1 in two intestinal epithelial cell lines representative of surface and crypt cell types.
In this study, gene expression of CXCL1 was increased in response to the invasive and adherent bacteria but not to V.
Attenuation of CXCL1 expression was mostly noted with higher concentrations of Lactobacillus.
Cedric Raine, the study explored the expression of CXCL1 when it interacts with myelin-producing cells, and found that the severity of the disease is reduced in a mouse model of multiple sclerosis (MS).
Although the role of CXCL1 in MS has not been previously explored, it's known that myelin-producing cells express immune receptors and respond to the immune molecule CXCL1.
For the study, the researchers examined the effects of CXCL1 specifically expressed in the nervous system in a mouse model of MS.
Based on their observations, the researchers came to the conclusion that CXCL1 might ay play a neuroprotective role in CNS autoimmune demyelination.