CX3CL1


Also found in: Wikipedia.

CX3CL1

A chemokine highly expressed in dendritic cells which is encoded by CX3CL1 on chromosome 16q13. CX3CL1 is thought to regulate leukocyte adhesion and migration in endothelium, given that membrane-bound CX3CL1 promotes adhesion of T cells and monocytes to endothelial cells.
References in periodicals archive ?
The membrane-anchored CX3CL1, which is induced in activated endothelial cells, enables the integrin-independent capture and firm adhesion of leukocytes via the Gi coupled receptor CX3CR1.
This study demonstrated that the TNF-[alpha]-induced expressions of CX3CL1 at mRNA and protein levels were also significantly inhibited by Tan I1A in HUVECs.
On the other hand, a neuron-generated signaling chemical, or fractalkine, also called CX3CL1, suppresses the activation of microglia.
Our study examined whether adding CX3CL1 beyond normal levels could decrease microglial activation and, therefore, play a neuroprotective role by helping prevent the loss of important neural cells in an animal model of Parkinson's disease," said Bickford.
Finally, a possible consequence of the CCL3L1 production might be quantitative or qualitative changes in leukocyte recruitment, similarly to what recently reported for CX3CL1 and its receptor CX3CR1 (16).
Specifically, Zhang implicated CX3CL1 molecules as contributing to plaque build-up in the arteries.