CVID


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Related to CVID: hypogammaglobulinemia, IVIG, common variable hypogammaglobulinemia

immunodeficiency

 [im″u-no-de-fish´en-se]
a deficiency of immune response or a disorder characterized by deficient immune response; classified as antibody (B cell), cellular (T cell), or combined deficiency disorders. Antibody immunodeficiencies are marked by hypo- or dysgammaglobulinemia, recurrent bacterial otitis media, and sinopulmonary infections. Cellular immunodeficiencies are characterized by recurrent low-grade or opportunistic infections, by graft-versus-host disease or reaction after blood transfusions, and by severe disease after immunization with live vaccines. See also acquired immunodeficiency syndrome.
common variable immunodeficiency (CVID) a heterogeneous group of disorders characterized by hypogammaglobulinemia, decreased antibody production in response to antigenic challenge, and recurrent pyogenic infections, often associated with hematologic and autoimmune disorders. Most patients have normal numbers of circulating B cells but lack plasma cells and appear to have an intrinsic defect of B cell differentiation. However, two other forms are also recognized: that due to a disorder of T lymphocyte regulation and that due to production of autoantibodies against T and B lymphocytes.
severe combined immunodeficiency (SCID) any of several rare congenital diseases, some of autosomal recessive and some of X-linked inheritance, in which both humoral and cell-mediated immunity fail to develop normally and T lymphocytes are absent or nearly so. In some forms, B lymphocytes are also absent. Early diagnosis is essential to prevent opportunistic infections. Persistent diarrhea, chronic mucocutaneous candidiasis, and failure to thrive may occur in infancy. Blood transfusions can result in graft-versus-host disease and routine vaccinations in fatal infection. Unless immune function is restored by a matched-donor bone marrow or fetal tissue transplantation or the patient is kept in complete isolation, the prognosis is poor.

CVID

common variable immunodeficiency.

CVID

CVID

Common variable immune deficiency, see there.
References in periodicals archive ?
The prevalence of CVID is found to be higher in northern European descent with an estimated incidence of between 1:50,000 and 1:200,000.
The signs and symptoms of CVID include hypogammaglobulinaemia (IgG, IgA, and/or IgM), poor titre response to vaccination with polysaccharide and protein antigens (e.
Rastad said, adding that her husband's mother has lupus, an autoimmune deficiency disease that could be an indicator of CVID.
It's hard to say how many people have CVID, as it takes a long time to diagnose from the onset of symptoms.
A 53-year-old white woman with a diagnosis of CVID had been receiving IVIG therapy for several years.
CVID is a primary immunodeficiency that affects the humoral arm of the immune system and interferes with the proper production of immunoglobulins.
The biological mechanisms that cause disease symptoms in CVID are still unclear," added Hakonarson, "but this study may suggest that altered function in CLEC16A and its associated proteins may represent a 'missing link' between immunodeficiency and autoimmunity in CVID.
Gastrointestinal involvement in CVID has been well documented.
The IL-12 cytokine family (including IL-12 and IL-23) is the master regulator of the TH1 pathway, which drives major chronic inflammatory diseases, including Crohn's disease, psoriasis, rheumatoid arthritis, multiple sclerosis and the gastrointestinal manifestations of CVID.
There are several thousand CVID patients in the United States and Europe.
CVID anticipates the Bedford Road project to begin construction in early Spring 2001, based on anticipated approval dates and unrelated construction schedules.
Most patients with CVID experience acute, recurring bacterial infections, including pneumonia, bronchitis and sinusitis.