CUL3

CUL3

A gene on chromosome 2q36.2 that encodes cullin-3, a core protein of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin-3 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The ubiquitin-protein ligase activity of the complex depends on neddylation of the cullin subunit, and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1.
References in periodicals archive ?
Cysteine-based regulation of the CUL3 adaptor protein Keap1.
Mutations and copy number alterations of NFE2L2 and KEAP1 and/or deletion or mutation of CUL3 were observed in 25-34% of SqCC among the classical alterations associated with this smoking-related histology subtype of lung cancer [77,84].