CUL2

CUL2

A gene on chromosome 10p11.21 that encodes cullin-2, a core protein of multiple cullin-RING-based ECS (elonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin-2 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The ubiquitin-protein ligase activity of the complex depends on neddylation of the cullin subunit, and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1.
References in periodicals archive ?
pombe); CHUK, conserved helix-loop-helix ubiquitous kinase; CREBBP, CREB binding protein (also known as CBP); CUL2, cullin 2; DAPK1, death-associated protein kinase 1; DAPK2, death-associated protein kinase 2; DAPK3, death-associated protein kinase 3; DGCR8, DiGeorge syndrome critical region gene 8; DROSHA, drosha, ribonuclease type III; E2F1, E2F transcription factor 1; EGF, epidermal growth factor; EGFL7, EGF-like-domain, multiple 7; EGFR, epidermal growth factor receptor; EGLN1, egl nine homolog 1 (C.
The Elongin pair, together with the CUL2 and RBX1 proteins, forms a tetrameric unit characterized as a mammalian E3 ligase, targeting proteins for ubiquitination and subsequent degradation.