EPHA2

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EPHA2

A gene on chromosome 1q36 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which promiscuously bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. Once activated by the ligand ephrin-A1 (EFNA1), it regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signalling pathway. It may participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.

During development, EPHA2 may function in distinctive aspects of pattern formation and development of several foetal tissues, such as angiogenesis, early hindbrain development and epithelial proliferation, and branching morphogenesis during mammary gland development. It is thought to regulate lens fibre cells’ shape and interactions and to be important for lens transparency development and maintenance. With ephrin-A2 (EFNA2), it may play a role in bone remodelling by regulating osteoclastogenesis and osteoblastogenesis.

EPHA2 interacts with ACP1, ANKS1A, ARHGEF16, CLDN4, DOCK4, ELMO2, INPPL1, PIK3R1, PIK3R2, PIK3R3, PTK2/FAK1, PTPN11, SLA, VAV2, and VAV3. 

Molecular pathology
Defects in EPHA2 cause cataract cortical age-related type 2 (age-related cataract cortical type 2) and cataract posterior polar type 1 (posterior polar cataracts type 2).
References in periodicals archive ?
5 minutes from the start of IV contrast administration for CTPA.
Both CTPA and VQS are excellent first-line investigations and their availability often determines the first choice.
CTPA is currently the diagnostic modality of choice for the diagnosis of PE.
The primary outcome of this study was the incidence of coagulopathy in patients who had acute PE confirmed by CTPA, and the diagnostic ability of coagulopathy in differentiating between acute PE and other respiratory pathologies in patients who had clinical symptoms and signs suggestive of acute PE requiring CTPA to exclude acute PE.
In multi-slice spiral CTPA where the results are known to be suspect, 23% of patients are likely to be false positives.
On the Columbian side, after the CTPA was signed it was submitted to the Colombian Congress in November 2006 and was approved in June 2007 and became a public law, Ley 143, in July 2007.
MYTH: YOU SHOULD ONLY USE NATURAL OR ORGANIC PRODUCTS ON BABIES' SKIN More than half of those polled by the CTPA believe 'natural' ingredients are better for children, and more than a third (36%) feel safer with 'organic'.
CTPA staffers are nationals from the United States and the other member countries who are employed by the OECD to organize and coordinate tax policy development among the member countries.
The taxation undertakings by the CTPA are governed by a Committee on Fiscal Affairs, consisting of representatives of the member countries.
According to the CTPA, PPD can't yet be replaced as "nothing else is as effective or as safe".
If not modified, the CTPA may benefit those in Colombia who obtained land violently and those criminal networks that may have infiltrated legal sectors of the Colombian economy.
The biggest issue in business and society is who do we trust," said CTPA chairman John Ballington.