IL10

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IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
References in periodicals archive ?
With over 200 members, CSIF holds workshops throughout the year, often in partnership with other organizations, member screenings, a five-month filmmaking intensive and summer media arts camps.
The film will be made in celluloid as opposed to digital, as are all films created with CSIF.
CSIF is a private investment company founded in 2005; its shareholders are Tsvetelina Borislavova and her foundation Credo Bonum.
The Calvert Moderate Allocation Fund seeks to achieve its investment objective by investing 50% to 80% of its net assets in underlying Calvert funds that invest primarily in equity securities, 20% to 50% of its net assets in CSIF Bond Portfolio, and 0% to 10% in the CSIF Money Market Portfolio.
Year-to-date ended June 30, 1998, CSIF MG ranked 65 out of 409 balanced funds, placing it in the first quintile.
The American Indian Coalition on Institution Accountability, a coalition of Indigenous organizations focused on the institutional social impact on the American Indian community recognizes CSIF as an investment leader and the first mutual fund to divest in apartheid within South Africa and also the first to re-invest in a free South Africa.
The CSIF Technology Fund will be the sixteenth addition to Calvert's family of socially screened funds.
99% of the Bulgarian-American Credit Bank, the CSIF announced.
In the context of investments, CSIF supports the United Nations' definition of indigenous peoples: "People having a historical continuity with pre-invasion and pre-colonial societies, who consider themselves distinct from other sectors of the societies now prevailing in those territories or parts of them with their own cultural patterns, social institutions and legal systems.