IL10

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IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
References in periodicals archive ?
For example, the academic partner shared her experience in research and the aging population and the CSIF partners shared their expertise in building community leadership, ability to implement organizational and programmatic functions, and knowledge of the community culture.
With over 200 members, CSIF holds workshops throughout the year, often in partnership with other organizations, member screenings, a five-month filmmaking intensive and summer media arts camps.
18 The "plus" unions are some regional unions, especially the Basque ELA-STV and the INTG in Galicia, the public sector union CSIF, and some smaller sector unions.
9% stake in the Bulgarian-American Credit Bank by Allied Irish Banks to Bulgarian private equity fund CSIF in the middle of June.
The Calvert Moderate Allocation Fund seeks to achieve its investment objective by investing 50% to 80% of its net assets in underlying Calvert funds that invest primarily in equity securities, 20% to 50% of its net assets in CSIF Bond Portfolio, and 0% to 10% in the CSIF Money Market Portfolio.
The projects that CSIF has bought are spread across the country, including installations in Ibaraki and Shizuoka prefectures on the eastern side of the island of Honshu.
The transaction is now pending clearance from Bulgaria's central bank and the antitrust watchdog, CSIF said without disclosing the value of the deal.
For the one-year ended June 30, 1998, CSIF MG ranked 63 out of 373 balanced funds, placing it in the first quintile.
Last month, AIB said it had signed an agreement to sell its shareholding in BACB "for an undisclosed amount" to CSIF, pending regulatory approval.
99% of the Bulgarian-American Credit Bank, the CSIF announced.
Description: The TA aims to support CSIF to set new technical as well as operational conditions to materialize the CSD RTGS Linkages for Delivery versus Payment (DVP) settlement of cross-currency repo and collateral arrangement, leading to the establishment of a new regional safety-net for safer and sound market management in ASEAN+3.
Dave Warrington, agricultural representative for Alliant Energy said, We have witnessed firsthand the positive impact CSIF has made on Iowa s farm families over the past decade and we are proud to invest in an organization that helps families grow and improve their farms responsibly .