DPYSL2

(redirected from CRMP-2)

DPYSL2

A gene on chromosome 8p22-p21 that encodes a member of the collapsin response mediator protein family, which forms homo- and heterotetramers. DPYSL2 plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration.  

Molecular pathology
DPYSL2 has been implicated in multiple neurological disorders; hyperphosphorylation of the encoded protein may play a role in the development of Alzheimer's disease.
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References in periodicals archive ?
The precise nature of the interaction between Vimpat([R]) and CRMP-2 and between CRMP-2 and seizure control is not known.
The precise nature of the interaction between Vimpat(R) and CRMP-2 and between CRMP-2 and seizure control is not known.
The interaction of lacosamide with CRMP-2 may prevent the formation of abnormal neuronal connections in the brain.