CRLF3

CRLF3

A gene on chromosome 17q11.2 that encodes a member of the cytokine receptor-like factor 3 family which is expressed in normal, premalignant (actinic keratosis) and malignant (squamous cell carcinoma) skin.
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To distinguish Type-1, Type-2, Type-3, and atypical NF1 microdeletions specifically, we decided to interrogate 3 regions within the NF1 gene (NF1-5', NF1 -C, and NF1-3'), 5 loci that closely flank REP-A, REP-B, REP-C, SUZ12, and its pseudogene (SUZ12P1) [TBC1D29, TBC1 domain family, member 29; CRLF3, cytokine receptor-like factor 3; RNF135, ring finger protein 135; UTP6, UTP6, small subunit (SSU) processome component, homolog (yeast); RHOT1, ras homolog family member T1], and 1 locus within SUZ12P1 (SUZ12P1).
For each admixture, the mean (SD) of the calculated RCN for the 6 loci (NF1-5', NF1 -C, NF1-3', CRLF3, RNF135, and UTP6) was plotted against the percentage of DNA with 2 NF1 copies present in the DNA admixture (Fig.
These samples were analyzed in duplicate, and for each admixture we plotted the mean (SD) of the calculated copy number of the 11 loci (from the CRLF3 3780 probe to the SUZ12 3786 probe) against the percentage of DNA with 2 NF1 copies present in the DNA admixture (Fig.