CRLF2

CRLF2

A gene on chromosome Xp22.3 and Yp11.3 that encodes a protein receptor for thymic stromal lymphopoietin (TSLP), which forms a functional complex with TSLP and IL7R and stimulates cell proliferation by activating STAT3 and STAT5, as well as JAK2. It is
implicated in the development of the haematopoietic system.
References in periodicals archive ?
In addition, rs1054564 was associated with trans expression of the CRLF2 (cytokine receptor-like factor 2) gene, located on chromosome Xp22.
14] Human genes: GDF15, growth differentiation factor 15; PGPEP1, pyroglutamyl-peptidase I; LRRC25, leucine rich repeat containing 25; CRLF2, cytokine receptor-like factor 2; LRRC31, leucine rich repeat containing 31.
He noted the importance of increasing participation of adults in clinical trials as well as researching further potential prognostic indicators including molecular markers such as the IKZF1, JAK, and CRLF2 gene mutation as a marker for high-risk disease.
In some ALL patients, chromosomal translocations create ABL1/NUP214 or P2RY8/ CRLF2 fusion proteins with oncogenic activity (41), (42).