CREST syndrome


Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia.

CREST syndrome

 
one of the less severe forms of systemic scleroderma, consisting of calcinosis of the skin, raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia. When esophageal dysfunction is not prominent, it is known as CRST syndrome.

CREST syn·drome

a variant of systemic sclerosis characterized by calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia.

CREST syndrome

[krest]
abbreviation for calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasis. CREST syndrome is a disease of skin and blood vessels and, in severe cases, the lungs, digestive tract, or heart. To be diagnosed with CREST, an individual must display at least two of the five symptoms. It is often associated with scleroderma.
enlarge picture
CREST syndrome
An acronym for the pentad of clinical signs seen with a limited form of scleroderma:
Calcinosis cutis
Raynaud’s phenomenon—at least a 2-phase colour change
Esophageal distal hypomotility or reflux esophagitis
Sclerodactyly or nonpitting digital edema
Telangiectasia; CREST has a slightly better prognosis than other connective tissue disorders, but has late complications—e.g., biliary cirrhosis and pulmonary hypertension
Lab Anticentromere antibodies are characteristic of CREST, but may also be seen in progressive systemic sclerosis, older women, or those with HLA-DR1

CREST syn·drome

(krest sin'drōm)
An acronymic designation for a variant of scleroderma characterized by calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia.

CREST syndrome

Acronym for a connective tissue disorder, related to progressive systemic sclerosis, but limited to CALCINOSIS, RAYNAUD'S PHENOMENON, oesophageal involvement, hardness of the fingers (Sclerodactyly) and dilated skin blood vessels (TELANGIECTASIA). The word forming the third letter of the acronym is spelt ‘esophageal’ in the USA.

Thibierge,

Georges, French physician, 1856-1926.
Thibierge-Weissenbach syndrome - calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia. Synonym(s): CREST syndrome

CREST syn·drome

(krest sin'drōm)
Acronym for variant of systemic sclerosis characterized by calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia.
References in periodicals archive ?
Moreover, the serologic confirmation of CREST syndrome in a patient without any digestive symptoms could have masked the presence of the gastric malignancy.
It is important to be aware that CREST syndrome and autoimmune thyroiditis can coexist and a thorough evaluation of both conditions and gastric cancer screening may be necessary even in patients who do not complain with digestive symptoms.
Small lymphocytic lymphoma in a patient with CREST syndrome.
Partial breast irradiation in a patient with bilateral breast cancers and CREST syndrome.
He was known to have had CREST syndrome since age 45, with a positive test for anticentromere antibody.
CREST syndrome was described first in 1964 as a combination of features mimicking hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome), but it has since been recognized as a relatively benign, slowly progressive variant of systemic scleroderma.
The case presented emphasizes that CREST syndrome may be associated with PBC and that the two conditions may occur in a man.