CREB1


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Related to CREB1: CREBBP, CREBP, KREB, CREB binding protein

CREB1

A gene on chromosome 2q34 that encodes a transcription factor of the leucine zipper family of DNA binding proteins, which binds as a homodimer to the cAMP-responsive element. CREB1 is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.
References in periodicals archive ?
The CREB1 gene encodes a regulatory protein (CREB) that orchestrates the expression of large numbers of other genes that play important roles in the brain.
Alterations in CREB1 expression have been reported in the brains of patients who died with major depression, those of animal models of major depression and related disorders and in the brains of animals treated with antidepressant drugs.
They found that CREB1 activates many genes linked to longevity and to the proper functioning of the brain.
CREB1 mediates the beneficial effects of the diet on the brain by turning on another group of molecules linked to longevity, the 'sirtuins'.
This finding is consistent with the fact that CREB1 is known to regulate important brain functions as memory, learning and anxiety control, and its activity is reduced or physiologically compromised by aging.