CREB1


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Related to CREB1: CREBBP, CREBP, KREB, CREB binding protein

CREB1

A gene on chromosome 2q34 that encodes a transcription factor of the leucine zipper family of DNA binding proteins, which binds as a homodimer to the cAMP-responsive element. CREB1 is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.
References in periodicals archive ?
Our systems biology analysis suggests a link between PCB 153 and IL-8 through CREB1 by one intermediate step from its primary target.
CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation.
Enhancement of memory-related long-term facilitation by ApAF, a novel transcription factor that acts downstream from both CREB1 and CREB2.
CREB1 mediates the beneficial effects of the diet on the brain by turning on another group of molecules linked to longevity, the 'sirtuins'.
This finding is consistent with the fact that CREB1 is known to regulate important brain functions as memory, learning and anxiety control, and its activity is reduced or physiologically compromised by aging.
Moreover, Italian researchers have discovered that the action of CREB1 can be dramatically increased by simply reducing caloric intake, and have shown that CREB is absolutely essential to make caloric restriction work on the brain.
15) These tumors of the GI tract share morphologic, immunohistochemical, and molecular similarities with our case, such as the presence of EWSR1 rearrangement in most cases, with 46% showing ATF1 and 22% showing CREB1 rearrangement.