CREB1

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Related to CREB: CREB binding protein

CREB1

A gene on chromosome 2q34 that encodes a transcription factor of the leucine zipper family of DNA binding proteins, which binds as a homodimer to the cAMP-responsive element. CREB1 is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.
References in periodicals archive ?
Moreover, we showed that CREB activation depends on AMPK activation because the AMPK inhibitor, cpdC, reduced CREB phosphorylation and nuclear translocation in kinsenoside-treated adipocytes (Fig.
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli.
We confirmed that PCB-95 activated CREB in hippocampal neurons as determined by Western blot analyses of pCREB expression, and we extended this finding to demonstrate that PCB-95 also up-regulated expression of the CREB-responsive gene Wnt2, as determined by qPCR.
Effects of miroestrol and estrogen on OVX-induced changes in the hippocampal and frontal cortex expression of genes encoding CREB and BDNF
Bill Kirk, CREB President, warned that while tight market conditions exist, “.
A recent study in a mouse model of Alzheimer's disease expressing abnormal CREB functioning demonstrated that delivery of the CBP gene into the brain increased the levels of a molecule known as brain-derived neurotrophic factor (BDNF), which correlated with improved learning and memory (Caccamo et al.
In the present study, we also observed a representative nongenomic proliferative effect, which presented as the paradoxical inverse U-shaped curve, and rapid activation of CREB and Rb.
The co-op owns and operates five landfill gas plants and received a $20 million CREB for landfill gas development.
Although the researchers weren't sure how CREB works in the brain, "we thought that maybe this protein is a common link" between the mechanisms of tobacco and morphine addiction, says Blendy.
Results of a study using the HaloCHIP[TM] System and high-throughput promoter assays demonstrate the ability to correlate DNA binding events to transcriptional activation or repression for the CREB transcription factor.
MTT, K252a, LY294002 and U0126 (Sigma, USA); rh[beta]-NGF (Pepro Tech, CA, USA); Rabbit polyclonal antibodies directed against TrkB, phospho-TrkB (Tyr515), PI3K, phosho-PI3K (Tyr467/199), Akt, phospho-Akt (Ser473), GSK30, phospho-GSK30 (S9), phosphoERK1/2 (Thr202/Tyr204), ERK1/2 (Bioworld Technology, USA); Rabbit polyclonal antibodies directed against CREB, phospho-CREB (Serl33) (Cell Signaling Technology, USA); Rabbit polyclonal antibodies directed against BDNF (Abeam, CA, USA).