CREB1

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Related to CREB: CREB binding protein

CREB1

A gene on chromosome 2q34 that encodes a transcription factor of the leucine zipper family of DNA binding proteins, which binds as a homodimer to the cAMP-responsive element. CREB1 is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.
References in periodicals archive ?
CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning.
CREB and Elk-1 phosphorylation by metabotropic glutamate receptors in striatal neurons (review).
Los autores proponen que el CREB en el hipocampo es un marcador molecular del reconocimiento espacial, y que los cambios bi-direccionales en el estado de fosforilacion de CREB se asocian con la exploracion de un ambiente familiar o novedoso (Sarantis et al.
Thus, the activation of CREB repressor by TAM does not impair initial encoding of STM, but LTM consolidation.
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli.
We confirmed that PCB-95 activated CREB in hippocampal neurons as determined by Western blot analyses of pCREB expression, and we extended this finding to demonstrate that PCB-95 also up-regulated expression of the CREB-responsive gene Wnt2, as determined by qPCR.
Las vias alternas de CREB pueden darse por medio de otra proteina de union a CREB (CBP); esta union ocurre por medio del dominio KIX de ambas moleculas y favorece la acetilacion de histonas con la consecuente expresion genetica (41, 42).
The Hebb rule, LTP, and CREB protein are associated with the formation of long-term memories.
These studies also found that blocking the activation of a transcription factor called CREB and a critical cell survival signaling kinase called Akt disrupted prostate cancer cell growth and induced cell death, a balance that is altered in cancer cells.
and State University of New York, Stony Brook, resulted from attempting to characterize a family of genes regulated by the "cAMP response element binding" protein, or CREB.
This study also investigated the effects of TBT exposure on CREB phosphorylation state utilizing specific antibodies to CREB and phosphorylated CREB.