CASP3

(redirected from CPP32)

CASP3

A gene on chromosome 4q34 that encodes a so-called effector caspase belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of apoptosis, as well as various stages of embryological development. CASP3 is highly expressed in the lung, spleen, heart, liver and kidney.
References in periodicals archive ?
2] may play a role as a mediator to induce apoptosis through release of cytochrome c to cytosol, activation of CPP32 protease, and PARP degradation (68).
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1[beta],-converting enzyme.
Caspase-3 also known as CPP32 (32 kDa cysteine protease) or apopain is a cysteine protease with aspartate specificity and a well-characterized effector of apoptosis.