HSPD1

(redirected from CPN60)

HSPD1

A gene on chromosome 2q33.1 that encodes a mitochondrial protein of the chaperonin family, which may function as a signalling molecule in the innate immune system. It is essential for the folding and assembly of newly imported proteins in mitochondria. HSPD1 is adjacent to a related gene; the region between the two acts as a bidirectional promoter.

Molecular pathology
HSPD1 mutations cause autosomal recessive spastic paraplegia 13.
References in periodicals archive ?
Bound to 30s ribosomal subunit 11 Binds to CPN60 in the presence of Mg- ATP and suppresses the ATPase activity of the latter 12 Binds to CPN60 in the presence of Mg- ATP and suppresses the ATPase activity of the latter 13 A molecular chaperone, thought to be involved in the initiation step of translation at high temperature.