a professor in the Duke Departments of Chemistry and Biochemistry, designed a molecule that could block the CPAF activity inside of human cells.
They found that when CPAF was blocked over time by their designed molecule, the protective home that the bacteria make for themselves within the infected cells degraded, and CPAF no longer could degrade the proteins in the cell that would normally mount an immune response to the infection.
When CPAF is inhibited, the infected human cells effectively "commit suicide," Valdivia said.
If a base fee is in the CPAF contract, the contractor will receive some amount above costs for best efforts.
Other programs that have used CPAF successfully appear to be recognizing the value of using a base fee.
The defense contractors interviewed at Fort Belvoir agreed in principle that in CPAF contracts, some amount of base fee for their best efforts would more clearly delineate the difference between payment for best efforts and payment for excellent performance (award fee), thereby reducing the criticism concerning the use of award fee contracts.
At the most recent review of progress against the CPAF indicators, the October 2010 XII Joint Budget Support Review, Government and its budget support partners agreed that Rwanda is making good progress in terms of EDPRS implementation and development partners commended the effective use of aid in Rwanda as shown by the progress achieved in all sectors.