CYP3A4

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CYP3A4

A gene on chromosome 7q21.1 that encodes a member of the cytochrome P450 superfamily of monooxygenases, which catalyse reactions in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 localises to the endoplasmic reticulum; its expression is induced by glucocorticoids and drugs. It metabolises roughly half of the drugs in current use today—e.g., paracetamol (acetaminophen), codeine, cyclosporin A, diazepam and erythromycin—as well as steroids and carcinogens.

CYP3A4

One isoenzyme form of the cytochrome P450 system involved in the metabolism of many drugs. Drugs that alter this enzyme system can influence the metabolism of other agents taken by patients and cause unanticipated toxic effects.
References in periodicals archive ?
CP33 is not restricted to highly erodible farmland, allowing for wider implementation in intensive agricultural landscapes where grassland habitat is often scarce.
CP33 buffers were planted with big bluestem (Andropogon gerardii), little bluestem (Schizachyrium scoparium), indiangrass (Sorghastrum nutans), partridge pea (Chamaecrista fasciculata), black-eyed susan (Rudbeckia hirta), and Maximilian sunflower (Helianthus maximiliani) in May 2004.
Chemilizer will provide Itronics Metallurgical with a GOLD'n GRO liquid fertilizer delivery system via two injectors, the HN55 and CP33, which will be used by Itronics Metallurgical's customers in lawn and landscape maintenance programs and by wholesale and retail nursery and greenhouse operators.
42) Foroon we oiss feawum wordum saedon, oy we woldongecyoan hu micel sio byroen bio oaes lareowdomes, oylces aenig hine underfon durre oara oe his unwieroe sie; CP33.
5% 15% VTR (in millions) CP46,067 CP33,986 36% EBITDA Margin (% of revenues) 34.
Riffell, Mississippi State University, "Mid-contract management effects on breeding grassland songbirds in CP33 habitat buffers in eastern Mississippi.
Results have now been received for hole CP33 which was drilled some 265 metres southwest of CPD21A.