COX-2


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Related to COX-2: Cox-1

COX-2

(kŏks′to͞o′)
n.
One of two isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins. It is specifically induced at sites of inflammation and can be selectively inhibited by certain NSAIDs in order to reduce pain.

COX-2

Cyclooxygenase-2 An enzyme primarily of immune-mediating cells–eg, macrophages, PMNs, and synoviocytes, which converts arachidonic acid into PGs 2º to inflammation. See COX-2 inhibitor.
References in periodicals archive ?
Given these results, he says, doctors should ascertain that a pancreatic tumor is producing COX-2 before they prescribe a COX-2 inhibitor.
For cox-2 inhibitors, the results of these trials will determine how they will compete with other NSAIDs.
Understand the progression and commercial impact of the safety concerns highlighted by the investigation into the Cox-2 class
A principal reason for ceasing the use of COX-2 Inhibitor drugs, cited by 86% of respondents, is patient apprehension in the wake of widespread media attention to their risks.
In addition, tests detected Cox-2 in precancerous lesions in the stomachs of nine other volunteers.
Because COX-2 inhibitors are relatively new, however, "nobody knows what the whole profile of side effects [from them] is; that's the downside," says Heinz-Josef Lenz of the University of Southern California in Los Angeles.
Extensive clinical trials are necessary to demonstrate the safety of using Cox-2 inhibitors over a prolonged period of time.
Continual monitoring of the progress of Celebrex and Bextra will further decide the future of Cox-2 inhibitors," says Elisa Perez, Research Analyst for the Frost & Sullivan Pharmaceuticals Group.
Fully understand the original rational behind the development of COX-2 inhibitors
Prime and Blue Cross and Blue Shield of Nebraska implemented the pre-authorization program for a large-size major account in January 2003 to diminish over-utilization of expensive Cox-2 drugs.
COX-2 drugs offer greater protection from adverse gastrointestinal events than lower-cost, traditional nonsteroidal anti-inflammatory drugs, although both types are equally effective in treating pain.