COX-2


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Related to COX-2: Cox-1

COX-2

(kŏks′to͞o′)
n.
One of two isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins. It is specifically induced at sites of inflammation and can be selectively inhibited by certain NSAIDs in order to reduce pain.

COX-2

Cyclooxygenase-2 An enzyme primarily of immune-mediating cells–eg, macrophages, PMNs, and synoviocytes, which converts arachidonic acid into PGs 2º to inflammation. See COX-2 inhibitor.
References in periodicals archive ?
that really deserves some attention," says Raymond DuBois, a COX-2 researcher at Vanderbilt-Ingram Cancer Center in Nashville.
For example, if the cox-2 inhibitors are only marginally more expensive than current prescription NSAIDs, then the cost impact of converting to cox-2 inhibitors would be relatively minimal.
There is no reason to think that inhibition of Cox-2 would not work [against] esophagus or stomach cancer, if it works in the colon," Ristimiiki says.
Mark's Hospital in London are studying whether COX-2 inhibitors prevent the formation of sometimes precancerous growths called polyps.